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Enzymatic degradation of hyaluronan hydrogels with different capacity for in situ bio-mineralization
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi, People's Republic of China.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
2018 (engelsk)Inngår i: Biopolymers, ISSN 0006-3525, E-ISSN 1097-0282, Vol. 109, nr 2, artikkel-id e23090Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In situ cross-linked hyaluronan (HA) hydrogels with different capacities for biomineralization were prepared and their enzymatic degradation was monitored. Covalent incorporation of bisphosphonates (BPs) into HA hydrogel results in the increased stiffness of the hydrogel in comparison with the unmodified HA hydrogel of the same cross-linking density. The rate of enzymatic degradation of HABP hydrogel was significantly lower than the rate of degradation of control HA hydrogel in vitro. This effect is observed only in the presence of calcium ions that strongly bind to the matrix-anchored BP groups and promote further mineralization of the matrix. The degradation of the hydrogels was followed by noninvasive fluorescence measurements enabled after mild and chemoselective labeling of cross-linkable HA derivatives with a fluorescent tag.

sted, utgiver, år, opplag, sider
2018. Vol. 109, nr 2, artikkel-id e23090
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Identifikatorer
URN: urn:nbn:se:uu:diva-334854DOI: 10.1002/bip.23090ISI: 000428629000004OAI: oai:DiVA.org:uu-334854DiVA, id: diva2:1160873
Forskningsfinansiär
EU, FP7, Seventh Framework ProgrammeTilgjengelig fra: 2017-11-28 Laget: 2017-11-28 Sist oppdatert: 2018-06-04bibliografisk kontrollert

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