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Vascular heterogeneity and specialization in development and disease
Max Planck Inst Heart & Lung Res, Angiogenesis & Metab Lab, Ludwigstr 43, D-61231 Bad Nauheim, Germany; Int Inst Mol & Cell Biol, PL-02109 Warsaw, Poland; DZHK German Ctr Cardiovasc Res, Partner Site Frankfurt, D-13347 Berlin, Germany.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Vascular Biology.ORCID iD: 0000-0002-9338-1257
2017 (English)In: Nature reviews. Molecular cell biology, ISSN 1471-0072, E-ISSN 1471-0080, Vol. 18, no 8, p. 477-494Article, review/survey (Refereed) Published
Abstract [en]

Blood and lymphatic vessels pervade almost all body tissues and have numerous essential roles in physiology and disease. The inner lining of these networks is formed by a single layer of endothelial cells, which is specialized according to the needs of the tissue that it supplies. Whereas the general mechanisms of blood and lymphatic vessel development are being defined with increasing molecular precision, studies of the processes of endothelial specialization remain mostly descriptive. Recent insights from genetic animal models illuminate how endothelial cells interact with each other and with their tissue environment, providing paradigms for vessel type- and organ-specific endothelial differentiation. Delineating these governing principles will be crucial for understanding how tissues develop and maintain, and how their function becomes abnormal in disease.

Place, publisher, year, edition, pages
2017. Vol. 18, no 8, p. 477-494
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-341859DOI: 10.1038/nrm.2017.36ISI: 000406040900008PubMedID: 28537573OAI: oai:DiVA.org:uu-341859DiVA, id: diva2:1183641
Funder
Swedish Research CouncilSwedish Cancer SocietyEU, European Research Council, 311546Knut and Alice Wallenberg FoundationMax Planck SocietyGerman Research Foundation (DFG), SFB 834EU, European Research Council, ERC-2014-CoG-646849Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2020-09-10Bibliographically approved

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Mäkinen, Taija

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