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Overall and peripheral lung function assessment by spirometry and forced oscillation technique in relation to asthma diagnosis and control.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Pediatrisk inflammationsforskning.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Pediatrisk inflammationsforskning.
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2017 (engelsk)Inngår i: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 47, nr 12, s. 1546-1554Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Classic spirometry is effort dependent and of limited value in assessing small airways. Peripheral airway involvement, and relation to poor control, in asthma, has been highlighted recently. Forced oscillation technique (FOT) offers an effort-independent assessment of overall and peripheral lung mechanics. We studied the association between lung function variables, obtained either by spirometry or multifrequency (5, 11 and 19 Hz) FOT, and asthma diagnosis and control.

METHODS: ), resistance difference between 5-19 Hz (R5-R19) and Asthma Control Test scores were determined in 234 asthmatic and 60 healthy subjects (aged 13-39 years). We used standardized lung function variables in logistic regression analyses, unadjusted and adjusted for age, height, gender and weight.

RESULTS: and R5-R19) were associated with uncontrolled asthma (P-values < .05).

CONCLUSIONS: /FVC, supporting a complementary role for FOT. Asthma control was related to FOT measures of peripheral airways, suggesting a potential use in identifying such involvement. Further studies are needed to determine a clinical value and relevant reference values in children, for the multifrequency FOT measurements.

sted, utgiver, år, opplag, sider
2017. Vol. 47, nr 12, s. 1546-1554
Emneord [en]
asthma, asthma control, forced oscillation technique, lung function, small airways, spirometry
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-342404DOI: 10.1111/cea.13035ISI: 000416430300005PubMedID: 28940832OAI: oai:DiVA.org:uu-342404DiVA, id: diva2:1184155
Tilgjengelig fra: 2018-02-20 Laget: 2018-02-20 Sist oppdatert: 2018-03-01bibliografisk kontrollert

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