Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4Show others and affiliations
2017 (English)In: Acta Diabetologica, ISSN 0940-5429, E-ISSN 1432-5233, Vol. 54, no 11, p. 1039-1045Article in journal (Refereed) Published
Abstract [en]
AIMS: Radiolabeled Exendin-4 has been proposed as suitable imaging marker for pancreatic beta cell mass quantification mediated by Glucagon-like peptide-1 receptor (GLP-1R). However, noticeable species variations in basal pancreatic uptake as well as uptake reduction degree due to selective beta cell ablation were observed.
METHODS: -Exendin4 Positron Emission Tomography (PET) in the same species. In vitro, ex vivo, and in vivo data formed the basis for calculating the theoretical in vivo contribution of each pancreatic compartment.
RESULTS: -Exendin4.
CONCLUSIONS: IPR as well as the exocrine GLP-1R density is the main determinants of the species variability in pancreatic uptake. Thus, the IPR in human is an important factor for assessing the potential of GLP-1R as an imaging biomarker for pancreatic beta cells.
Place, publisher, year, edition, pages
2017. Vol. 54, no 11, p. 1039-1045
Keywords [en]
Animal models, Beta cell imaging, Beta cell mass, Exendin4, GLP-1R, Positron emission tomography
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:uu:diva-342527DOI: 10.1007/s00592-017-1046-2ISI: 000413142300008PubMedID: 28891030OAI: oai:DiVA.org:uu-342527DiVA, id: diva2:1184567
2018-02-212018-02-212018-02-23Bibliographically approved