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Regional gastrointestinal contractility parameters using the wireless motility capsule: inter-observer reproducibility and influence of age, gender and study country
Aalborg Univ, Aalborg Univ Hosp, Aalborg & Clin Inst, Mech Sense,Dept Gastroenterol & Hepatol, Aalborg, Denmark.;Queen Mary Univ London, Neurogastroenterol Grp, Ctr Neurosci & Trauma, Blizard Inst,Wingate Inst Neurogastroenterol,Bart, London, England.;Univ Hosp North Midlands, Dept Gastroenterol, Stoke On Trent, Staffs, England..
Aarhus Univ Hosp, Dept Clin Biochem, Aarhus, Denmark..
Funct Gut Clin, London, England..
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2018 (Engelska)Ingår i: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 47, nr 3, s. 391-400Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background:

The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. Aims: To describe normative values for motility/contractility parameters across age, gender and testing centres.

Methods:

Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators.

Results:

Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r = .24, P = .01; r = .22, P = .02; and r = .2, P = .04 respectively). Small bowel motility index was higher in females than males (150.412 vs 122 +/- 7.6, P = .04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic log(e) motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P < .0003) but not with transit times.

Conclusions:

Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.

Ort, förlag, år, upplaga, sidor
2018. Vol. 47, nr 3, s. 391-400
Nationell ämneskategori
Gastroenterologi
Identifikatorer
URN: urn:nbn:se:uu:diva-341481DOI: 10.1111/apt.14438ISI: 000419586100008PubMedID: 29210098OAI: oai:DiVA.org:uu-341481DiVA, id: diva2:1186445
Tillgänglig från: 2018-02-28 Skapad: 2018-02-28 Senast uppdaterad: 2018-02-28Bibliografiskt granskad

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Hellström, Per M.

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