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Variations in the practice of molecular radiotherapy and implementation of dosimetry: results from a European survey
Lund Univ, Dept Med Radiat Phys, Clin Sci Lund, Lund, Sweden..
Cardiff Univ, Sch Engn, Cardiff, S Glam, Wales..
Charles Univ Prague, Motol Univ Hosp, Dept Nucl Med & Endocrinol, Fac Med 2, Prague, Czech Republic..
Gurutzeta Cruces Univ Hosp, Dept Med Phys & Radiat Protect, Baracaldo, Spain..
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2017 (Engelska)Ingår i: EJNMMI Physics, ISSN 2197-7364, E-ISSN 2191-219X, Vol. 4, artikel-id 28Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and in view of the Council Directive (2013/59/Euratom), there is a need to understand the current availability of dosimetry-based MRT in clinical practice and research studies. The aim of this study was to assess the current practice of MRT and dosimetry across European countries.

Methods: An electronic questionnaire was distributed to European countries. This addressed 18 explicitly considered therapies, and for each therapy, a similar set of questions were included. Questions covered the number of patients and treatments during 2015, involvement of medical specialties and medical physicists, implementation of absorbed dose planning, post-therapy imaging and dosimetry, and the basis of therapy prescription.

Results: Responses were obtained from 26 countries and 208 hospitals, administering in total 42,853 treatments. The most common therapies were I-131-NaI for benign thyroid diseases and thyroid ablation of adults. The involvement of a medical physicist (mean over all 18 therapies) was reported to be either minority or never by 32% of the responders. The percentage of responders that reported that dosimetry was included on an always/majority basis differed between the therapies and showed a median value of 36%. The highest percentages were obtained for Lu-177-PSMA therapy (100%), Y-90 microspheres of glass (84%) and resin (82%), I-131-mIBG for neuroblastoma (59%), and I-131-NaI for benign thyroid diseases (54%). The majority of therapies were prescribed based on fixed-activity protocols. The highest number of absorbed-dose based prescriptions were reported for Y-90 microsphere treatments in the liver (64% and 96% of responses for resin and glass, respectively), I-131-NaI treatment of benign thyroid diseases (38% of responses), and for I-131-mIBG treatment of neuroblastoma (18% of responses).

Conclusions: There is a wide variation in MRT practice across Europe and for different therapies, including the extent of medical-physicist involvement and the implementation of dosimetry-guided treatments.

Ort, förlag, år, upplaga, sidor
2017. Vol. 4, artikel-id 28
Nyckelord [en]
Molecular radiotherapy, Radionuclide therapy, Radiopharmaceutical therapy, European survey, Dosimetry
Nationell ämneskategori
Radiologi och bildbehandling
Identifikatorer
URN: urn:nbn:se:uu:diva-343903DOI: 10.1186/s40658-017-0193-4ISI: 000416955300001PubMedID: 29199391OAI: oai:DiVA.org:uu-343903DiVA, id: diva2:1187181
Forskningsfinansiär
Vetenskapsrådet, 621-2014-6187Tillgänglig från: 2018-03-02 Skapad: 2018-03-02 Senast uppdaterad: 2018-03-02Bibliografiskt granskad

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