uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Demography and mating system shape the genome-wide impact of purifying selection in Arabis alpina
Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden..
Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden..
Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution.
Show others and affiliations
2018 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 115, no 4, p. 816-821Article in journal (Refereed) Published
Abstract [en]

Plant mating systems have profound effects on levels and structuring of genetic variation and can affect the impact of natural selection. Although theory predicts that intermediate outcrossing rates may allow plants to prevent accumulation of deleterious alleles, few studies have empirically tested this prediction using genomic data. Here, we study the effect of mating system on purifying selection by conducting population-genomic analyses on whole-genome resequencing data from 38 European individuals of the arctic-alpine crucifer Arabis alpina. We find that outcrossing and mixed-mating populations maintain genetic diversity at similar levels, whereas highly self-fertilizing Scandinavian A. alpina show a strong reduction in genetic diversity, most likely as a result of a postglacial colonization bottleneck. We further find evidence for accumulation of genetic load in highly self-fertilizing populations, whereas the genome-wide impact of purifying selection does not differ greatly between mixed-mating and outcrossing populations. Our results demonstrate that intermediate levels of outcrossing may allow efficient selection against harmful alleles, whereas demographic effects can be important for relaxed purifying selection in highly selfing populations. Thus, mating system and demography shape the impact of purifying selection on genomic variation in A. alpina. These results are important for an improved understanding of the evolutionary consequences of mating system variation and the maintenance of mixed-mating strategies.

Place, publisher, year, edition, pages
NATL ACAD SCIENCES , 2018. Vol. 115, no 4, p. 816-821
Keyword [en]
self-fertilization, demographic history, bottleneck, fitness effects, genetic load
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-343798DOI: 10.1073/pnas.1707492115ISI: 000423097800070PubMedID: 29301967OAI: oai:DiVA.org:uu-343798DiVA, id: diva2:1187484
Funder
Swedish National Infrastructure for Computing (SNIC), snic2014-1-194, b2013022, b2013237Swedish Research CouncilScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Available from: 2018-03-05 Created: 2018-03-05 Last updated: 2018-03-05Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Ågren, Jon

Search in DiVA

By author/editor
Ågren, Jon
By organisation
Plant Ecology and Evolution
In the same journal
Proceedings of the National Academy of Sciences of the United States of America
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf