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Fruit and vegetable consumption and risk of cholecystectomy: a prospective cohort study of women and men.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
2018 (English)In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 57, no 1, p. 75-81Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Epidemiologic data on whether consumption of fruit and vegetables (FVs) decreases the risk of gallstone disease are sparse. Therefore, we examined the association between FV consumption and the 14-year risk of symptomatic gallstone disease (defined as occurrence of cholecystectomy) in a large group of middle-aged and elderly persons.

METHODS: Data from two population-based cohorts were used, which included 74,554 men and women (born 1914-1952). Participants filled in a food frequency questionnaire in the late fall of 1997 and were followed up for cholecystectomy between 1998 and 2011 via linkage to the Swedish Patient Register. Cox regression models were used to obtain hazard ratios (HRs).

RESULTS:  = .43). The multivariable-adjusted HR was 0.95 (95 % CI 0.83-1.08) for the highest compared with the lowest sex-specific quartile of FV consumption. There was no evidence of interactions with age (P = .25) or sex (P = .72) in analyses pooled by sex. However, an age-by-FV consumption interaction was observed in separate analyses of women (P = .010), with decreased HRs of cholecystectomy for ages up to 60 years.

CONCLUSIONS: This study supports an inverse association between FV consumption and risk cholecystectomy in women, although the association was restricted to women aged 48-60 years. In contrast, the study does not support an association in men.

Place, publisher, year, edition, pages
2018. Vol. 57, no 1, p. 75-81
Keywords [en]
Cohort study, Fruit consumption, Gallbladder disease, Vegetable consumption
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-344289DOI: 10.1007/s00394-016-1298-6PubMedID: 27544676OAI: oai:DiVA.org:uu-344289DiVA, id: diva2:1187965
Available from: 2018-03-06 Created: 2018-03-06 Last updated: 2018-03-06

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