uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Spectrum of lymphomas across different drug treatment groups in rheumatoid arthritis: a European registries collaborative project
Univ Manchester, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England..
German Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany..
Univ Paris Sud, Hop Univ Paris Sud, Dept Rheumatol, Le Kremlin Bicetre, France..
Univ Manchester, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England..
Vise andre og tillknytning
2017 (engelsk)Inngår i: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 76, nr 12, s. 2025-2030Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background Lymphomas comprise a heterogeneous group of malignant diseases with highly variable prognosis. Rheumatoid arthritis (RA) is associated with a twofold increased risk of both Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). It is unknown whether treatment with biologic disease-modifying antirheumatic drugs (bDMARDs) affect the risk of specific lymphoma subtypes.

Methods Patients never exposed to (bionaïve) or ever treated with bDMARDs from 12 European biologic registers were followed prospectively for the occurrence of first ever histologically confirmed lymphoma. Patients were considered exposed to a bDMARD after having received the first dose. Lymphomas were attributed to the most recently received bDMARD.

Results Among 124 997 patients (mean age 59 years; 73.7% female), 533 lymphomas were reported. Of these, 9.5% were HL, 83.8% B-cell NHL and 6.8% T-cell NHL. No cases of hepatosplenic T-cell lymphoma were observed. Diffuse large B-cell lymphoma (DLBCL) was the most frequent B-cell NHL subtype (55.8% of all B-cell NHLs). The subtype distributions were similar between bionaïve patients and those treated with tumour necrosis factor inhibitors (TNFi). For other bDMARDs, the numbers of cases were too small to draw any conclusions. Patients with RA developed more DLBCLs and less chronic lymphocytic leukaemia compared with the general population.

Conclusion This large collaborative analysis of European registries has successfully collated subtype information on 533 lymphomas. While the subtype distribution differs between RA and the general population, there was no evidence of any modification of the distribution of lymphoma subtypes in patients with RA treated with TNFi compared with bionaïve patients.

sted, utgiver, år, opplag, sider
2017. Vol. 76, nr 12, s. 2025-2030
Emneord [en]
DMARDs(biologic), anti-TNF, epidemiology, rheumatoid arthritis
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-344205DOI: 10.1136/annrheumdis-2017-211623ISI: 000417061500017PubMedID: 28822981OAI: oai:DiVA.org:uu-344205DiVA, id: diva2:1188092
Tilgjengelig fra: 2018-03-06 Laget: 2018-03-06 Sist oppdatert: 2018-03-06bibliografisk kontrollert

Open Access i DiVA

fulltext(315 kB)88 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 315 kBChecksum SHA-512
22f55e9dcf66c8f63d4e691ed91613f1a506ce9cd3796bec42b33a0085867d8fe542326c661c4ab7178d72cb77720f29d31ebcba3cb7d4151d92cd1ae527ca6e
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Baecklund, Eva

Søk i DiVA

Av forfatter/redaktør
Baecklund, Eva
Av organisasjonen
I samme tidsskrift
Annals of the Rheumatic Diseases

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 88 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 71 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf