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Microdialysis as an Important Technique in Systems Pharmacology: a Historical and Methodological Review
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.ORCID iD: 0000-0002-9181-1321
2017 (English)In: AAPS Journal, ISSN 1550-7416, E-ISSN 1550-7416, Vol. 19, no 5, p. 1294-1303Article, review/survey (Refereed) Published
Abstract [en]

Microdialysis has contributed with very important knowledge to the understanding of target-specific concentrations and their relationship to pharmacodynamic effects from a systems pharmacology perspective, aiding in the global understanding of drug effects. This review focuses on the historical development of microdialysis as a method to quantify the pharmacologically very important unbound tissue concentrations and of recent findings relating to modeling microdialysis data to extrapolate from rodents to humans, understanding distribution of drugs in different tissues and disease conditions. Quantitative microdialysis developed very rapidly during the early 1990s. Method development was in focus in the early years including development of quantitative microdialysis, to be able to estimate true extracellular concentrations. Microdialysis has significantly contributed to the understanding of active transport at the blood-brain barrier and in other organs. Examples are presented where microdialysis together with modeling has increased the knowledge on tissue distribution between species, in overweight patients and in tumors, and in metabolite contribution to drug effects. More integrated metabolomic studies are still sparse within the microdialysis field, although a great potential for tissue and disease-specific measurements is evident.

Place, publisher, year, edition, pages
2017. Vol. 19, no 5, p. 1294-1303
Keywords [en]
microdialysis, pharmacodynamics, pharmacokinetics, pharmacology, recovery methods, systems
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-345884DOI: 10.1208/s12248-017-0108-2ISI: 000408407300006PubMedID: 28762127OAI: oai:DiVA.org:uu-345884DiVA, id: diva2:1189875
Available from: 2018-03-13 Created: 2018-03-13 Last updated: 2018-03-13Bibliographically approved

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Hammarlund-Udenaes, Margareta

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