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Heterogeneity in retinoblastoma: a tale of molecules and models
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
S T Eriks Ogonsjukhus, Karolinska Inst, Stockholm, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Developmental Neuroscience.
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2017 (English)In: CLINICAL AND TRANSLATIONAL MEDICINE, ISSN 2001-1326, Vol. 6, article id 42Article, review/survey (Refereed) Published
Abstract [en]

Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that can affect RB1 resulting in different clinical outcomes. In addition, other transformations, such as MYCN amplification, generate particularly aggressive tumors, which may or may not be RB1 independent. Recognizing the cellular characteristics required for tumor development, by identifying the elusive cell-of-origin for retinoblastoma, would help us understand the development of these tumors. In this review we summarize the heterogeneity reported in retinoblastoma on a molecular, cellular and tissue level. We also discuss the challenging heterogeneity in current retinoblastoma models and suggest future platforms that could contribute to improved understanding of tumor initiation, progression and metastasis in retinoblastoma, which may ultimately lead to more patient-specific treatments.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD , 2017. Vol. 6, article id 42
Keywords [en]
Cancer, Cell-of-origin, Genetics, Horizontal cells, MYCN, Photoreceptors, OTX2, RB1
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-346610DOI: 10.1186/s40169-017-0173-2ISI: 000414747600001OAI: oai:DiVA.org:uu-346610DiVA, id: diva2:1192261
Available from: 2018-03-22 Created: 2018-03-22 Last updated: 2019-01-22Bibliographically approved

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Stenfelt, SonyaHallböök, FinnBoije, Henrik

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