uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Large-scale brain simulation and disorders of consciousness: Mapping technical and conceptual issues
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Centrum för forsknings- och bioetik. Science and Society Unit, Biogem Genetic Research Centre, Ariano Irpino (AV), Italy. (Neuroethics)ORCID-id: 0000-0002-3298-7829
Science for Life Laboratory, School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Neuroscience, Karolinska Institute, Solna, Sweden. (Neuroscience)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Centrum för forsknings- och bioetik.
2018 (engelsk)Inngår i: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 9, artikkel-id 585Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Modelling and simulations have gained a leading position in contemporary attempts to describe, explain, and quantitatively predict the human brain's operations. Computer models are highly sophisticated tools developed to achieve an integrated knowledge of the brain with the aim of overcoming the actual fragmentation resulting from different neuroscientific approaches. In this paper we investigate plausibility of simulation technologies for emulation of consciousness and the potential clinical impact of large-scale brain simulation on the assessment and care of disorders of consciousness (DOCs), e.g. Coma, Vegetative State/Unresponsive Wakefulness Syndrome, Minimally Conscious State.Notwithstanding their technical limitations, we suggest that simulation technologies may offer new solutions to old practical problems, particularly in clinical contexts. We take DOCs as an illustrative case, arguing that the simulation of neural correlates of consciousness is potentially useful for improving treatments of patients with DOCs.

sted, utgiver, år, opplag, sider
2018. Vol. 9, artikkel-id 585
Emneord [en]
Consciousness, Consciousness Disorders, brain modeling, Neuroethics, brain simulation
HSV kategori
Forskningsprogram
Neurovetenskap; Filosofi
Identifikatorer
URN: urn:nbn:se:uu:diva-347782DOI: 10.3389/fpsyg.2018.00585ISI: 000430833800001PubMedID: 29740372OAI: oai:DiVA.org:uu-347782DiVA, id: diva2:1195844
Prosjekter
The human brain project
Forskningsfinansiär
EU, Horizon 2020, 720270Tilgjengelig fra: 2018-04-06 Laget: 2018-04-06 Sist oppdatert: 2019-08-30bibliografisk kontrollert
Inngår i avhandling
1. Brain, consciousness and disorders of consciousness at the intersection of neuroscience and philosophy
Åpne denne publikasjonen i ny fane eller vindu >>Brain, consciousness and disorders of consciousness at the intersection of neuroscience and philosophy
2019 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

The present dissertation starts from the general claim that neuroscience is not neutral, with regard to theoretical questions like the nature of consciousness, but it needs to be complemented with dedicated conceptual analysis. Specifically, the argument for this thesis is that the combination of empirical and conceptual work is a necessary step for assessing the significant questions raised by the most recent study of the brain. Results emerging from neuroscience are conceptually very relevant in themselves but, notwithstanding its theoretical sophistication, neuroscience is not sufficient to provide a complete interpretation or an appropriate understanding of their impact. Consequently, the present thesis starts from the need for an interdisciplinary and hybrid field of research, i.e. fundamental neuroethics.

Within this framework, the thesis takes consciousness and related disorders (i.e. Vegetative State/Unresponsive Wakefulness Syndrome, Minimally Conscious State and Coma) and the addicted brain as illustrative cases of the potential fruitful collaboration between empirical and conceptual investigations.

The general goal of the thesis is to contribute to the overall development of bridging the gap between empirical and conceptual understandings of consciousness. The first paper sets the theoretical framework, providing an empirically-based description of the brain with significant philosophical implications for an understanding of consciousness. The last three papers of the thesis try to apply the theoretical framework to illustrative cases. Papers II and III analyse the possible application of science and technology for an easier detection and clinical care of patients with disorders of consciousness, with particular attention to communication mediated by neurotechnology and the simulation of the conscious brain, respectively; paper IV provides a potentially new ethical analysis of addiction within the elaborated general conceptual framework.

The conclusion of the thesis is that the impact of neuroscientific results needs that a dedicated conceptual approach reveals and investigates their conceptual meaning. This conceptual analysis is not exclusive but integrative and complementary to the empirical science. The case of consciousness, analysed from both an ethical and conceptual point of view, is highly illustrative in this respect. In the end, a conceptual/linguistic work of clarification is urgently needed.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2019. s. 63
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1597
Emneord
Brain; consciousness; disorders of consciousness; neuroethics; neurophilosophy
HSV kategori
Forskningsprogram
Filosofi; Neurovetenskap
Identifikatorer
urn:nbn:se:uu:diva-392187 (URN)978-91-513-0749-7 (ISBN)
Disputas
2019-10-30, Sal IX, Universitetshuset, Biskopsgatan 3, Uppsala, 09:00 (engelsk)
Opponent
Veileder
Prosjekter
Human Brain Project
Forskningsfinansiär
EU, Horizon 2020, 785907
Tilgjengelig fra: 2019-10-07 Laget: 2019-08-30 Sist oppdatert: 2019-10-15

Open Access i DiVA

fulltext(260 kB)166 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 260 kBChecksum SHA-512
8071652333fd92c5ca6d9dc585ce7846db1e2c383916726657be4d0814e3705274180f4c4eb779c2b63001d1a6f2563b0a186d36172d94e687c8c54bb5191922
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Farisco, MicheleEvers, Kathinka

Søk i DiVA

Av forfatter/redaktør
Farisco, MicheleEvers, Kathinka
Av organisasjonen
I samme tidsskrift
Frontiers in Psychology

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 166 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 207 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf