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Impaired cognitive ability at 2.5 years predicts later visual and ophthalmological problems in children born very preterm
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Perinatal, Neonatal and Pediatric Cardiology Research.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Perinatal, Neonatal and Pediatric Cardiology Research.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology.
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2018 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 107, no 5, p. 822-830Article in journal (Refereed) Published
Abstract [en]

Aim: To identify possible predictive factors for visual problems at 6.5 years in children born very preterm.

Methods: During 2004–2007, all very preterm infants (gestational age [GA] <32 weeks) in Uppsala County, Sweden were screened for retinopathy of prematurity (ROP) neonatally; at four months, visual tracking was tested; at 2.5 years, visuospatial and cognitive tests were carried out. At 6.5 years, 84 preterm children and a reference group of 64 full‐term children underwent ophthalmological testing.

Results: Mean visual acuity (VA) did not differ between the groups, but subnormal VA (≤0.8) was more common in the preterm group (31% vs 14%; p < 0.05). More often than full‐term children, preterm children had impaired contrast sensitivity (<0.5) (36% vs 19%; p < 0.05) and strabismus (8% vs 0%; p < 0.05). Low GA, ROP, intraventricular haemorrhage 3‐4/periventricular leukomalacia and cognitive disability at 2.5 years predicted ophthalmological and visual problems at 6.5 years. Visual tracking ability at four months was not predictive of ophthalmological outcome.

Conclusion: Children born preterm had more ophthalmological problems at 6.5 years of age, including subtle dysfunctions. ROP, early brain injury and impaired cognitive function around 2.5 years predicted later ophthalmological dysfunctions.

Place, publisher, year, edition, pages
2018. Vol. 107, no 5, p. 822-830
Keywords [en]
Cognition, Long term, Risk factor, Very preterm, Visual outcome
National Category
Ophthalmology Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-348648DOI: 10.1111/apa.14209ISI: 000430115100016PubMedID: 29288532OAI: oai:DiVA.org:uu-348648DiVA, id: diva2:1198095
Available from: 2018-04-16 Created: 2018-04-16 Last updated: 2018-06-19Bibliographically approved

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Hreinsdottir, JoninaKaul, Ylva FredrikssonHellström-Westas, LenaRosander, Kerstinvon Hofsten, ClaesHolmström, Gerd

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OphthalmologyPerinatal, Neonatal and Pediatric Cardiology ResearchDepartment of Psychology
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