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Increased plasma cathepsin S and trombospondin-1 in patients with acute ST-segment elevation myocardial infarction
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.ORCID iD: 0000-0003-3161-0402
2019 (English)In: Cardiology journal, ISSN 1897-5593, Vol. 26, no 4, p. 385-393Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The role of cathepsins in the pathological progression of atherosclerotic lesions in ischemic heart disease have been defined in detail more than numerous times. This investigation examined the platelet-specific biomarker trombospondin-1 (TSP-1) and platelet function ex vivo, and compared this with cathepsin S (Cat-S; a biomarker unrelated to platelet activation but also associated this with increased mortality risk) in patients with ST segment elevation myocardial infarction (STEMI).

METHODS: The STEMI patients were divided into two groups depending on the degree of coronary vessel occlusion: those with closed (n = 90) and open culprit vessel (n = 40). Cat-S and TSP-1 were analyzed before, 1-3 days after and 3 months after percutanous coronary intervention (PCI).

RESULTS: During acute STEMI, plasma TSP-1 was significantly elevated in patients with closed culprit lesions, but rapidly declined after PCI. In fact, TSP-1 after PCI was significantly lower inpatient samples compared to healthy individuals. In comparison, plasma Cat-S was significantly elevated both before and after PCI. In patients with closed culprit lesions, Cat-S was significantly higher compared to patients with open culprit lesions 3 months after PCI. Although troponin-I were higher (p < 0.01) in patients with closed culprit lesion, there was no correlation with Cat-S and TSP-1.

CONCLUSIONS: Cat-S but not TSP-1 may be a useful risk biomarker in relation to the severity of STEMI. However, the causality of Cat-S as a predictor for long-term mortality in STEMI remains to be ascertained in future studies.

Place, publisher, year, edition, pages
2019. Vol. 26, no 4, p. 385-393
Keywords [en]
ST segment elevation myocardial infarction, cathepsin S, percutaneous coronary intervention, platelets
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-349225DOI: 10.5603/CJ.a2018.0030ISI: 000483031700010PubMedID: 29611169OAI: oai:DiVA.org:uu-349225DiVA, id: diva2:1200119
Funder
AFA InsuranceAvailable from: 2018-04-23 Created: 2018-04-23 Last updated: 2019-10-02Bibliographically approved

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