uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neurology.ORCID iD: 0000-0002-2251-5879
Show others and affiliations
2018 (English)In: Journal of Neurology, ISSN 0340-5354, E-ISSN 1432-1459, Vol. 265, no 6, p. 1432-1442Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls.

METHODS: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures.

RESULTS: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood.

CONCLUSIONS: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor ***for developing glioma-related seizures or glioma.

Place, publisher, year, edition, pages
2018. Vol. 265, no 6, p. 1432-1442
Keywords [en]
Epileptic seizures, Glioma-related seizures, Observational study (cohort, case–control), Primary brain tumor
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-349379DOI: 10.1007/s00415-018-8857-0ISI: 000434462300023PubMedID: 29687214OAI: oai:DiVA.org:uu-349379DiVA, id: diva2:1201573
Available from: 2018-04-26 Created: 2018-04-26 Last updated: 2018-08-30Bibliographically approved

Open Access in DiVA

fulltext(783 kB)76 downloads
File information
File name FULLTEXT01.pdfFile size 783 kBChecksum SHA-512
6adc5e0f8af05898ccedefaa7cdd32f01fcf42e2df23ce5f7417b1199928ea2822c6b89338ae80d89d445273f980b3db57bc351e41e12dc1d7708c2482cd96d6
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Berntsson, Shala G.Smits, Anja

Search in DiVA

By author/editor
Berntsson, Shala G.Smits, Anja
By organisation
Neurology
In the same journal
Journal of Neurology
Neurology

Search outside of DiVA

GoogleGoogle Scholar
Total: 76 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 123 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf