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Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Karolinska Inst, Inst Environm Med, Stockholm, Sweden; Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden.ORCID iD: 0000-0003-2710-8620
Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Dept Pathophysiol & Allergy Res, Div Immunopathol, Vienna, Austria.
Karolinska Inst, Inst Environm Med, Stockholm, Sweden; Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden.
Imperial Coll, Dept Paediat, London, England.
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2017 (English)In: EBioMedicine, ISSN 0360-0637, E-ISSN 2352-3964, Vol. 26, p. 91-99Article in journal (Refereed) Published
Abstract [en]

Background: Sensitization in early childhood may precede respiratory allergy in adolescence.

Methods: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16 years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16 years. Clinically and independent relevant allergen molecules accounting for ≥ 90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11 years (N = 248) and the outcome was studied at 11 years.

Findings: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to ≥ 3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16 years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16 years were 100% and 100%, respectively, for IgE reactivity to ≥ 3 of 5 risk molecules.

Interpretations: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16 years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children.

Place, publisher, year, edition, pages
2017. Vol. 26, p. 91-99
Keywords [en]
Asthma, IgE, Prediction, Rhinitis, Sensitisation
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-348798DOI: 10.1016/j.ebiom.2017.11.009ISI: 000425875200017PubMedID: 29221963OAI: oai:DiVA.org:uu-348798DiVA, id: diva2:1203675
Funder
Swedish Asthma and Allergy AssociationSwedish Heart Lung FoundationCancer and Allergy FoundationKing Gustaf V Jubilee FundMagnus Bergvall FoundationForte, Swedish Research Council for Health, Working Life and WelfareAvailable from: 2018-05-04 Created: 2018-05-04 Last updated: 2018-05-04Bibliographically approved

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