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DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular Medicine. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0001-8699-9959
Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden..
Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden..
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2018 (English)In: Clinical Epigenetics, E-ISSN 1868-7083, Vol. 10, article id 31Article in journal (Refereed) Published
Abstract [en]

Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients.

Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data.

Results: Among the 137 patients that later relapsed, patients with a CIMP-profile (n = 42) at initial diagnosis had an inferior overall survival (pOS(5years) 33%) compared to CIMP+ patients (n = 95, pOS(5years) 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors.

Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD , 2018. Vol. 10, article id 31
Keywords [en]
DNA methylation, BCP-ALL, Prognosis, CIMP, Relapse, Risk stratification
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-350877DOI: 10.1186/s13148-018-0466-3ISI: 000427080200001PubMedID: 29515676OAI: oai:DiVA.org:uu-350877DiVA, id: diva2:1210260
Funder
Swedish Research CouncilSwedish Cancer SocietySwedish Childhood Cancer FoundationThe Kempe FoundationsMagnus Bergvall FoundationKnut and Alice Wallenberg Foundation
Note

De två första författarna delar förstaförfattarskapet.

Available from: 2018-05-28 Created: 2018-05-28 Last updated: 2019-10-23Bibliographically approved

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Nordlund, JessicaFrost, Britt-MariePalle, JosefineLönnerholm, Gudmar

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Nordlund, JessicaFrost, Britt-MariePalle, JosefineLönnerholm, Gudmar
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Molecular MedicineScience for Life Laboratory, SciLifeLabDepartment of Women's and Children's Health
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