uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Minimizing inequality in access to precision medicine in breast cancer by real-time population-based molecular analysis in the SCAN-B initiative
Lund Univ, Surg, Dept Clin Sci Lund, Lund, Sweden.;Skane Univ Hosp, Dept Surg, Med Serv, Lund, Sweden..
Lund Univ, Oncol & Pathol, Dept Clin Sci Lund, Lund, Sweden.;Skane Univ Hosp, Dept Haematol Oncol & Radiotherapy, Med Serv, Lund, Sweden..
Lund Univ, Dept Lab Med Lund, Translat Canc Res, Lund, Sweden..
Lund Univ, Oncol & Pathol, Dept Clin Sci Lund, Lund, Sweden..
Show others and affiliations
2018 (English)In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 105, no 2, p. E158-E168Article in journal (Refereed) Published
Abstract [en]

Background: Selection of systemic therapy for primary breast cancer is currently based on clinical biomarkers along with stage. Novel genomic tests are continuously being introduced as more precise tools for guidance of therapy, although they are often developed for specific patient subgroups. The Sweden Cancerome Analysis Network - Breast (SCAN-B) initiative aims to include all patients with breast cancer for tumour genomic analysis, and to deliver molecular subtype and mutational data back to the treating physician.

Methods: An infrastructure for collection of blood and fresh tumour tissue from all patients newly diagnosed with breast cancer was set up in 2010, initially including seven hospitals within the southern Sweden regional catchment area, which has 1.8 million inhabitants. Inclusion of patients was implemented into routine clinical care, with collection of tumour tissue at local pathology departments for transport to the central laboratory, where routines for rapid sample processing, RNA sequencing and biomarker reporting were developed.

Results: More than 10 000 patients from nine hospitals have currently consented to inclusion in SCAN-B with high (90 per cent) inclusion rates from both university and secondary hospitals. Tumour samples and successful RNA sequencing arc being obtained from more than 70 per cent of patients, showing excellent representation compared with the national quality registry as a truly population-based cohort. Molecular biomarker reports can be delivered to multidisciplinary conferences within 1 week.

Conclusion: Population-based collection of fresh tumour tissue is feasible given a decisive joint effort between academia and collaborative healthcare groups, and with governmental support. An infrastructure for genomic analysis and prompt data output paves the way for novel systemic therapy for patients from all hospitals, irrespective of size anti location.

Place, publisher, year, edition, pages
WILEY , 2018. Vol. 105, no 2, p. E158-E168
National Category
Surgery Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-351772DOI: 10.1002/bjs.10741ISI: 000429002100016PubMedID: 29341157OAI: oai:DiVA.org:uu-351772DiVA, id: diva2:1213315
Funder
Swedish Cancer Society, CAN 2016/659VINNOVA, 2014-00484Available from: 2018-06-04 Created: 2018-06-04 Last updated: 2018-06-04Bibliographically approved

Open Access in DiVA

fulltext(3482 kB)79 downloads
File information
File name FULLTEXT01.pdfFile size 3482 kBChecksum SHA-512
3c6292b9901a70af5e098af0faca4ad92724eebf82c01c92ef9232abc1656180479464830807970eb4559bbcb7dbce95f1c3b4fb3d4c5fa6258c1bd491429067
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Lindman, Henrik

Search in DiVA

By author/editor
Lindman, Henrik
By organisation
Experimental and Clinical Oncology
In the same journal
British Journal of Surgery
SurgeryCancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
Total: 79 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 97 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf