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Effect of long-term exposure to oxazepam on whole-body cortisol concentration in stickleback
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Biology Education Centre.
2018 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Pharmaceuticals are common contaminants in aquatic ecosystems. Pharmaceutical residues in aquatic systems have gained increased interest the last decades and are now recognized as a major threat to aquatic ecosystems around the globe. Benzodiazepines (BZDs) are a class of psychiatric pharmaceuticals classified as anxiolytics, i.e. pharmaceuticals used to treat anxiety disorders. A study reports that dilute concentrations of the BZD oxazepam influences fish behavior, which potentially can damage ecosystems. The objective of this study was to investigate the effect of a 7-day exposure to the benzodiazepine oxazepam (1 or 100 ug/L tank water) on whole-body cortisol concentration in three-spined stickleback (Gasterosteus aculeatus). Cortisol concentrations were measured using RIA (Radioimmunoassay). Our results show that the highest oxazepam concentration (100 μg/L) we tested displayed a significantly reduced cortisol concentrations compared to controls when analyzed separately. But when fish were exposed to the lower concentration of oxazepam (1 μg/L), an effect on cortisol levels was not shown. After all, our results show that oxazepam have no effect on cortisol levels and therefore will not influence the behavior of three-spined stickleback regarding cortisol. Our result contradicts several earlier studies and it is imperative to do further studies regarding this manner using other protocols. The complexity of how benzodiazepines affect aquatic life and ecosystems remains largely unknown and environmental predictions are difficult to make. However, it is necessary to study how pharmaceuticals potentially can affect aquatic life because of its alarming effects.

Place, publisher, year, edition, pages
2018.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-355811OAI: oai:DiVA.org:uu-355811DiVA, id: diva2:1231083
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Available from: 2018-08-22 Created: 2018-07-05 Last updated: 2018-08-22Bibliographically approved

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The full text will be freely available from 2020-07-20 11:59
Available from 2020-07-20 11:59

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