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Effect of long-term exposure to oxazepam on whole-body cortisol concentration in stickleback
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för biologisk grundutbildning.
2018 (Engelska)Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
Abstract [en]

Pharmaceuticals are common contaminants in aquatic ecosystems. Pharmaceutical residues in aquatic systems have gained increased interest the last decades and are now recognized as a major threat to aquatic ecosystems around the globe. Benzodiazepines (BZDs) are a class of psychiatric pharmaceuticals classified as anxiolytics, i.e. pharmaceuticals used to treat anxiety disorders. A study reports that dilute concentrations of the BZD oxazepam influences fish behavior, which potentially can damage ecosystems. The objective of this study was to investigate the effect of a 7-day exposure to the benzodiazepine oxazepam (1 or 100 ug/L tank water) on whole-body cortisol concentration in three-spined stickleback (Gasterosteus aculeatus). Cortisol concentrations were measured using RIA (Radioimmunoassay). Our results show that the highest oxazepam concentration (100 μg/L) we tested displayed a significantly reduced cortisol concentrations compared to controls when analyzed separately. But when fish were exposed to the lower concentration of oxazepam (1 μg/L), an effect on cortisol levels was not shown. After all, our results show that oxazepam have no effect on cortisol levels and therefore will not influence the behavior of three-spined stickleback regarding cortisol. Our result contradicts several earlier studies and it is imperative to do further studies regarding this manner using other protocols. The complexity of how benzodiazepines affect aquatic life and ecosystems remains largely unknown and environmental predictions are difficult to make. However, it is necessary to study how pharmaceuticals potentially can affect aquatic life because of its alarming effects.

Ort, förlag, år, upplaga, sidor
2018.
Nationell ämneskategori
Naturvetenskap
Identifikatorer
URN: urn:nbn:se:uu:diva-355811OAI: oai:DiVA.org:uu-355811DiVA, id: diva2:1231083
Handledare
Examinatorer
Tillgänglig från: 2018-08-22 Skapad: 2018-07-05 Senast uppdaterad: 2018-08-22Bibliografiskt granskad

Open Access i DiVA

Publikationen är tillgänglig i fulltext från 2020-07-20 11:59
Tillgänglig från 2020-07-20 11:59

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