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Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 22, nr 9, artikkel-id E1514Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Four new flavones with modified prenyl groups, namely (E)-5-hydroxytephrostachin (1), purleptone (2), (E)-5-hydroxyanhydrotephrostachin (3), and terpurlepflavone (4), along with seven known compounds (5-11), were isolated from the CH₂Cl₂/MeOH (1:1) extract of the stem of Tephrosia purpurea subsp. leptostachya, a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence. Some of the isolated compounds showed antiplasmodial activity against the chloroquine-sensitive D6 strains of Plasmodium falciparum, with (E)-5-hydroxytephrostachin (1) being the most active, IC50 1.7 ± 0.1 μM, with relatively low cytotoxicity, IC50 > 21 μM, against four cell-lines.

sted, utgiver, år, opplag, sider
2017. Vol. 22, nr 9, artikkel-id E1514
Emneord [en]
Tephrosia purpurea subsp. leptostachya, antiplasmodial, cytotoxicity, flavone, stem
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-355957DOI: 10.3390/molecules22091514PubMedID: 28891957OAI: oai:DiVA.org:uu-355957DiVA, id: diva2:1231920
Tilgjengelig fra: 2018-07-10 Laget: 2018-07-10 Sist oppdatert: 2018-07-10

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