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Genetic architecture of traits associated with reproductive barriers in Silene:: Coupling, sex chromosomes and variation
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. (Section of Plant Ecology and Evolution)
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. (Section of Plant Ecology and Evolution)ORCID iD: 0000-0002-7146-588X
2018 (English)In: Molecular Ecology, ISSN 0962-1083, E-ISSN 1365-294X, Vol. 27, no 19, p. 3889-3904Article in journal (Refereed) Published
Abstract [en]

The evolution of reproductive barriers and their underlying genetic architecture is ofcentral importance for the formation of new species. Reproductive barriers can becontrolled either by few large-effect loci suggesting strong selection on key traits,or by many small-effect loci, consistent with gradual divergence or with selection onpolygenic or multiple traits. Genetic coupling between reproductive barrier loci fur-ther promotes divergence, particularly divergence with ongoing gene flow. In thisstudy, we investigated the genetic architectures of ten morphological, phenologicaland life history traits associated with reproductive barriers between the hybridizingsister species Silene dioica and S. latifolia; both are dioecious with XY-sex determina-tion. We used quantitative trait locus (QTL) mapping in two reciprocal F2crosses.One to six QTLs per trait, including nine major QTLs (PVE > 20%), were detectedon 11 of the 12 linkage groups. We found strong evidence for coupling of QTLs foruncorrelated traits and for an important role of sex chromosomes in the geneticarchitectures of reproductive barrier traits. Unexpectedly, QTLs detected in the twoF2crosses differed largely, despite limited phenotypic differences between themand sufficient statistical power. The widely dispersed genetic architectures of traitsassociated with reproductive barriers suggest gradual divergence or multifariousselection. Coupling of the underlying QTLs likely promoted divergence with geneflow in this system. The low congruence of QTLs between the two crosses furtherpoints to variable and possibly redundant genetic architectures of traits associatedwith reproductive barriers, with important implications for the evolutionary dynam-ics of divergence and speciation.

Place, publisher, year, edition, pages
2018. Vol. 27, no 19, p. 3889-3904
Keywords [en]
adaptation, ddRAD-seq, genetic coupling, QTL, reproductive barrier, speciation
National Category
Genetics Evolutionary Biology
Research subject
Biology with specialization in Evolutionary Genetics
Identifiers
URN: urn:nbn:se:uu:diva-356980DOI: 10.1111/mec.14562ISI: 000446838400012PubMedID: 29577481OAI: oai:DiVA.org:uu-356980DiVA, id: diva2:1237748
Funder
Swedish Research Council, 2012-03622Available from: 2018-08-09 Created: 2018-08-09 Last updated: 2019-03-11Bibliographically approved
In thesis
1. Mechanisms of speciation in Silene
Open this publication in new window or tab >>Mechanisms of speciation in Silene
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A fundamental question in the field of evolutionary biology is how new species originate. Investigating speciation benefits from an integrated approach, which requires a solid understanding of ecology, reproductive biology, geographical distribution, underlying genetic architecture of reproductive isolation (RI), demographic history and genomic divergence. In this thesis, I studied the evolution of reproductive isolation in the sister species Silene dioica (L.) Clairv. and S. latifolia Poiret. The aims of the thesis are to investigate (1) the individual and cumulative contributions of extrinsic and intrinsic reproductive barriers between S. dioica and S. latifolia, (2) the genetic architecture of traits associated with reproductive barriers (3) the demographic history of lineage-split between the two species, (4) genomic patterns of divergence between the species.

I found that multiple extrinsic pre- and postzygotic barriers resulting from ecological differentiation contributed most to total RI, while intrinsic barriers had substantial individual strength but contributed weakly to total RI. QTL mapping revealed evidence for genetic coupling of QTLs controlling traits associated with RI, although QTLs were overall widely distributed. QTLs related to sexually dimorphic traits were located on or near the pseudo-autosomal region of the sex chromosomes. The best-supported demographic model suggests heterogeneous population size and migration rates among genome-wide loci and points to the presence of barrier loci. Genomic divergence (measured using FST and dXY) was commonly accentuated around the middle of linkage groups and near QTLs for traits associated with reproductive barriers.

In summary, the results in my thesis indicate that the speciation process is driven by multiple interacting and complex reproductive barriers. The genomic divergence landscape is shaped by interplay of the magnitude of gene flow, the strength and timing of selection, and other  confounding factors such as genomic features.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2018. p. 42
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1699
Keywords
speciation, reproductive isolation, Silene, ddRAD-seq
National Category
Natural Sciences
Research subject
Biology with specialization in Evolutionary Genetics
Identifiers
urn:nbn:se:uu:diva-356989 (URN)978-91-513-0398-7 (ISBN)
Public defence
2018-09-27, Lindahlsalen, Evolution Biological Center, EBC Norbyvägen 14-18, Uppsala, 14:00 (English)
Opponent
Supervisors
Available from: 2018-09-06 Created: 2018-08-09 Last updated: 2019-03-11

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Liu, XiaodongKarrenberg, Sophie

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