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Recurrence Risk After Up-to-Date Colon Cancer Staging, Surgery, and Pathology: Analysis of the Entire Swedish Population.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. (Sjöblom)ORCID iD: 0000-0003-1621-7872
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology. (Glimelius)ORCID iD: 0000-0002-5440-791x
2018 (English)In: Diseases of the Colon & Rectum, ISSN 0012-3706, E-ISSN 1530-0358, Vol. 61, no 9, p. 1016-1025Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Developments in the quality of care of patients with colon cancer have improved surgical outcome and thus the need for adjuvant chemotherapy.

OBJECTIVE: To investigate the recurrence rate in a large population-based cohort after modern staging, surgery, and pathology have been implemented.

DESIGN: This was a retrospective registry study.

SETTINGS: Data from patients included in the Swedish Colorectal Cancer Registry covering 99% of all cases and undergoing surgery for colon cancer stages I to III between 2007 and 2012 were obtained.

PATIENTS: In total, 14,325 patients who did not receive any neoadjuvant treatment, underwent radical surgery, and were alive 30 days after surgery were included.

MAIN OUTCOME MEASURES: Tumor and node classification and National Comprehensive Cancer Network-defined risk factors for recurrence were used to assess overall and stage-specific 5-year recurrence rates.

RESULTS: The median follow-up of nonrecurrent cases was 77 months (range, 47-118 mo). The 5-year recurrence rate was 5% in stage I, 12% in stage II, and 33% in stage III patients. In patients classified as having pT3N0 cancer with no or 1 risk factor, the 5-year recurrence rates were 9% and 11%. Risk factors for shorter time to recurrence were male sex, more advanced pT and pN classification, vascular and perineural invasion, emergency surgery, lack of central ligature, short longitudinal resection margin, postoperative complications, and, in stage III, no adjuvant chemotherapy.

LIMITATIONS: The registry does not contain some recently identified factors of relevance for recurrence rates, and some late recurrences may be missing.

CONCLUSIONS: The recurrence rate is less than that previously observed in historical materials, but current, commonly used risk factors are still useful in evaluating recurrence risks. Stratification by pT and pN classification and the number of risk factors enables the identification of large patient groups characterized by such a low recurrence rate that it is questionable whether adjuvant treatment is motivated. See Video Abstract at http://links.lww.com/DCR/A663.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018. Vol. 61, no 9, p. 1016-1025
Keywords [en]
Chemotherapy adjuvant, Colonic neoplasms, Humans, Registries, Retrospective studies, Sweden
National Category
Cancer and Oncology
Research subject
Oncology; Surgery; Pathology
Identifiers
URN: urn:nbn:se:uu:diva-357138DOI: 10.1097/DCR.0000000000001158ISI: 000441866000009PubMedID: 30086050OAI: oai:DiVA.org:uu-357138DiVA, id: diva2:1238142
Funder
Swedish Cancer Society, CAN 2016/447Available from: 2018-08-13 Created: 2018-08-13 Last updated: 2018-10-10Bibliographically approved

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Osterman, ErikGlimelius, Bengt

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