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Synthetic green fluorescent protein (GFP) chromophore analog for rapid, selective and sensitive detection of cyanide in water and in living cells
Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India.
Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Univ Mumbai, Dept Chem, Bombay 400098, Maharashtra, India.
2018 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 265, p. 257-263Article in journal (Refereed) Published
Abstract [en]

Here, we report Green Fluorescent Protein (GFP) chromophore analog as a turn-on fluorescent chemodosimeter (THBI) for selective detection of cyanide in water, on solid state and in living cells. The detection limit was found to be 0.17 mu M (4.5 ppb). The time dependent study revealed that there is a rapid enhancement in fluorescence intensity (in less than 5s) and was constant over the period of 1 h. Cell imaging data exhibited that THBI was successfully crossed cell membrane and visualized fluorescence response in live HCT cells. 

Place, publisher, year, edition, pages
ELSEVIER SCIENCE SA , 2018. Vol. 265, p. 257-263
Keywords [en]
GFP, HBI, THBI, Cyanide chemodosimeter, Fluorogenic chemosensor
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-356375DOI: 10.1016/j.snb.2018.03.068ISI: 000430232500031OAI: oai:DiVA.org:uu-356375DiVA, id: diva2:1239172
Available from: 2018-08-15 Created: 2018-08-15 Last updated: 2018-08-15Bibliographically approved

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Nawale, Ganesh N.

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