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Novel activities of safe-in-human broad-spectrum antiviral agents
Norwegian Univ Sci & Technol, Dept Clin & Mol Med, N-7028 Trondheim, Norway.
Univ Tartu, Inst Technol, EE-50090 Tartu, Estonia.
Univ Helsinki, Dept Virol, FIN-00014 Helsinki, Finland.
Umea Univ, Dept Clin Microbiol, S-90185 Umea, Sweden.
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2018 (English)In: Antiviral Research, ISSN 0166-3542, E-ISSN 1872-9096, Vol. 154, p. 174-182Article in journal (Refereed) Published
Abstract [en]

According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning existing safe-inhuman antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we reviewed all approved, investigational and experimental antiviral agents, which are safe in man, and identified 59 compounds that target at least three viral diseases. We tested 55 of these compounds against eight different RNA and DNA viruses. We found novel activities for dalbavancin against echovirus 1, ezetimibe against human immunodeficiency virus 1 and Zika virus, as well as azacitidine, cyclosporine, minocycline, oritavancin and ritonavir against Rift valley fever virus. Thus, the spectrum of antiviral activities of existing antiviral agents could be expanded towards other viral diseases.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 154, p. 174-182
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-357378DOI: 10.1016/j.antiviral.2018.04.016ISI: 000433651300021PubMedID: 29698664OAI: oai:DiVA.org:uu-357378DiVA, id: diva2:1239277
Funder
European Regional Development Fund (ERDF)Available from: 2018-08-16 Created: 2018-08-16 Last updated: 2018-09-28Bibliographically approved

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Öhrmalm, ChristinaBondeson, KåreBergqvist, Anders

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