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Individual biological sensitivity to environmental influences: testing the differential susceptibility properties of the 5HTTLPR polymorphism in relation to depressive symptoms and delinquency in two adolescent general samples
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.ORCID iD: 0000-0002-3589-6113
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.ORCID iD: 0000-0002-8853-2508
2018 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 125, no 6, p. 977-993Article in journal (Refereed) Published
Abstract [en]

The gene-environment interaction research field in psychiatry has traditionally been dominated by the diathesis-stress framework, where certain genotypes are assumed to confer increased risk for adverse outcomes in a stressful environment. In later years, theories of differential susceptibility, or biological sensitivity, suggest that candidate genes that interact with environmental events do not exclusively confer a risk for behavioural or psychiatric disorders but rather seem to alter the sensitivity to both positive and negative environmental influences. The present study investigates the susceptibility properties of the serotonin transporter-linked polymorphic region (5HTTLPR) in relation to depressive symptoms and delinquency in two separate adolescent community samples: n = 1457, collected in 2006; and n = 191, collected in 2001. Two-, three-, and four-way interactions between the 5HTTLPR, positive and negative family environment, and sex were found in relation to both depressive symptoms and delinquency. However, the susceptibility properties of the 5HTTLPR were distinctly less pronounced in relation to depressive symptoms. If the assumption that the 5HTTLPR induces differential susceptibility to both positive and negative environmental influences is correct, the previous failures to measure and control for positive environmental factors might be a possible explanation for former inconsistent findings within the research field.

Place, publisher, year, edition, pages
2018. Vol. 125, no 6, p. 977-993
Keywords [en]
Antisocial behaviour, Depression, Emotion regulation, Gene-environment interaction, Human, SERT, SLC6A4
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-357554DOI: 10.1007/s00702-018-1854-8ISI: 000433116200010PubMedID: 29427067OAI: oai:DiVA.org:uu-357554DiVA, id: diva2:1239770
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2015-00897Forte, Swedish Research Council for Health, Working Life and WelfareAvailable from: 2018-08-17 Created: 2018-08-17 Last updated: 2018-08-17Bibliographically approved

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Åslund, CeciliaNilsson, Kent W.

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