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Milk-Related Symptoms and Immunoglobulin E Reactivity in Swedish Children from Early Life to Adolescence
Stockholm Cty Council, Ctr Occupat & Environm Med, S-11365 Stockholm, Sweden;Karolinska Inst, Inst Environm Med, S-17111 Stockholm, Sweden.
Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, S-17176 Stockholm, Sweden;South Gen Hosp, Sachs Children & Youth Hosp, S-11883 Stockholm, Sweden;Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.ORCID iD: 0000-0002-5478-7019
Karolinska Inst, Inst Environm Med, S-17111 Stockholm, Sweden;South Gen Hosp, Sachs Children & Youth Hosp, S-11883 Stockholm, Sweden.
Karolinska Inst, Inst Environm Med, S-17111 Stockholm, Sweden;South Gen Hosp, Sachs Children & Youth Hosp, S-11883 Stockholm, Sweden;Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.
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2018 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 10, no 5, article id 651Article in journal (Refereed) Published
Abstract [en]

Cow's milk often causes symptoms in infants. Whereas, some continue to experience symptoms through childhood, others become tolerant. Yet, the ages at which persistence and tolerance occur are less clear. Thus, we examined the age of onset and persistence of milk-related symptoms from early life to adolescence, and Immunoglobulin E (IgE) milk reactivity, focusing on gender differences in a large, population-based birth cohort. Overall, 20.0% (537/2985) of children, with a comparable gender distribution, had early life milk-related symptoms. At 16y, approximately 2% (62/2985) children had persistent symptoms and high milk IgE levels (e.g., median at 4 years: 1.5 kU(A)/L) that were beginning in early life. In contrast, 94% had transient symptoms and low median IgE levels (early life: 0.63 kU(A)/L, 8y: 0.72 kU(A)/L; 16 years: 1.1 kU(A)/L). Also, at 16 years, approximately 6% of females and 3% of males without any previously reported symptoms reported adolescent-onset of symptoms (p < 0.001). Such symptoms were almost exclusively gastrointestinal symptoms and were not associated with detectable IgE. In conclusion, early life milk-related symptoms are common, although most cases are transient by 16 years. Twice as many females vs. males report adolescent-onset symptoms, and particularly gastrointestinal symptoms. Children with persistent symptoms have both a higher prevalence and higher milk IgE levels, as compared to other phenotypes.

Place, publisher, year, edition, pages
MDPI , 2018. Vol. 10, no 5, article id 651
Keywords [en]
adolescent, allergy, anaphylaxis, child, food hypersensitivity, Immunoglobulin E, milk
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-359670DOI: 10.3390/nu10050651ISI: 000435196000125PubMedID: 29883392OAI: oai:DiVA.org:uu-359670DiVA, id: diva2:1245574
Funder
Swedish Research CouncilForte, Swedish Research Council for Health, Working Life and WelfareSwedish Research Council FormasStockholm County CouncilSwedish Heart Lung FoundationSwedish Asthma and Allergy AssociationEU, FP7, Seventh Framework Programme, 261357Available from: 2018-09-05 Created: 2018-09-05 Last updated: 2018-09-05Bibliographically approved

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Wickman, Magnus

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