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Lifestyle factors and disease-specific differences in subgroups of Swedish Myasthenia Gravis
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Clinical Neurophysiology.ORCID iD: 0000-0002-8250-1575
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Landtblom: Neurology.ORCID iD: 0000-0001-9567-470x
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Rostedt Punga: Clinical Neurophysiology.ORCID iD: 0000-0002-2178-9413
2018 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 138, no 6, p. 557-565Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To evaluate disease-specific differences between Myasthenia Gravis (MG) subgroups and compare patterns of lifestyle between MG patients and population controls.

METHODS: All MG patients (n=70) in Jönköping County, Sweden, were invited to answer a disease-specific questionnaire, containing questions about disease-specific data, lifestyle, co-morbidity and mental fatigue. The patients were clinically evaluated. Four hundred age- and gender matched population controls were invited to answer the non-disease-specific part of the questionnaire. Disease-specific issues were compared between MG subgroups. Lifestyle related factors and concomitant conditions were compared to the population controls.

RESULTS: Forty MG patients and 188 population controls participated in the study. In the late onset MG (LOMG; N=18) subgroup, the male predominance was higher than previously reported. In the early onset MG (EOMG; N=17) subgroup, time to diagnosis was longer, fatigue was higher and bulbar weakness was the dominant symptom (65%). Compared to their matched population controls, LOMG patients were more obese (OR 13.7, p=0.015), ate less fish (OR 4.1, p=0.012), tended to smoke more (OR 4.1, p=0.086) and tended to be employed as manual laborers more often (OR 2.82, p=0.083). Mental health problems and sickness benefits were more common among MG patients than in controls and MG patients were less regularly doing focused physical activity.

CONCLUSIONS: It is important to consider disease-specific differences when tailoring the management of individual MG patients. There is a need for improved knowledge on how to apply primary and secondary prevention measures to lifestyle disorders in MG patients without risk of deterioration.

Place, publisher, year, edition, pages
2018. Vol. 138, no 6, p. 557-565
Keywords [en]
Early-onset MG, MG subgroups, Myasthenia Gravis, environmental factors, fatigue, late-onset MG, lifestyle
National Category
Neurology
Identifiers
URN: urn:nbn:se:uu:diva-359968DOI: 10.1111/ane.13017ISI: 000449696000012PubMedID: 30155967OAI: oai:DiVA.org:uu-359968DiVA, id: diva2:1246416
Funder
Swedish Research Council, VR-523-2014-2048Available from: 2018-09-07 Created: 2018-09-07 Last updated: 2019-06-27Bibliographically approved

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Westerberg, ElisabetLandtblom, Anne-MarieRostedt Punga, Anna

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