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Modeling the structural implications of an alternatively spliced Exoc3l2, a paralog of the tunneling nanotube-forming M-Sec
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology.ORCID iD: 0000-0003-3117-5367
Zurich Univ, Zurich Univ Hosp, Clin Neurosci Ctr, Dept Neurosurg, Zurich, Switzerland.
Univ Gothenburg, Inst Biomed, Dept Clin Chem & Transfus Med, Sahlgrenska Acad, Gothenburg, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. (Kreuger)ORCID iD: 0000-0002-2055-7776
2018 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, no 8, article id e0201557Article in journal (Refereed) Published
Abstract [en]

The exocyst is a molecular tether that retains secretory vesicles at the plasma membrane prior to SNARE-mediated docking and fusion. However, individual exocyst complex components (EXOCs) may also function independently of exocyst assembly. Alternative splice variants of EXOC mRNA and paralogs of EXOC genes have been described and several have been attributed functions that may be independent of the exocyst complex. Here we describe a novel splice variant of murine Exoc3l2, which we term Exoc3l2a. We discuss possible functional implications of the resulting domain excision from this isoform of EXOC3L2 based on structural similarities with its paralog M-Sec (EXOC3L3), which is implicated in tunneling nanotube formation. The identification of this Exoc3l2 splice variant expands the potential for subunit diversity within the exocyst and for alternative functionality of this component independently of the exocyst.

Place, publisher, year, edition, pages
San Francisco, California, US, 2018. Vol. 13, no 8, article id e0201557
National Category
Cell and Molecular Biology
Research subject
Medical Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-360991DOI: 10.1371/journal.pone.0201557ISI: 000441129300022PubMedID: 30086153OAI: oai:DiVA.org:uu-360991DiVA, id: diva2:1249785
Funder
The Dementia Association - The National Association for the Rights of the DementedSwedish Cancer Society, CAN 2014/820Available from: 2018-09-20 Created: 2018-09-20 Last updated: 2018-11-28Bibliographically approved

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O'Callaghan, PaulKreuger, Johan

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