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Persistence of immune response to an adjuvanted varicella-zoster virus subunit vaccine for up to year nine in older adults
Standort Juliusspital, Klinikum Wurzburg Mitte, Lab Med & Vaccinat, Wurzburg, Germany.
GSK, Clin R&D, Wavre, Belgium.
GSK, R&D, Clin Evidence Generat, Biostat & Stat Programming, Wavre, Belgium.
Univ Def, Fac Mil Hlth Sci, Dept Epidemiol, Hradec Kralove, Czech Republic.
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2018 (English)In: Human Vaccines & Immunotherapeutics, ISSN 2164-5515, E-ISSN 2164-554X, Vol. 14, no 6, p. 1370-1377Article in journal (Refereed) Published
Abstract [en]

Background: In adults aged 60years, two doses of the herpes zoster subunit vaccine (HZ/su; 50 mu g varicella-zoster virus glycoprotein E [gE] and AS01(B) Adjuvant System) elicited humoral and cell-mediated immune responses persisting for at least six years. We assessed immunogenicity nine years post-initial vaccination.Methods: This open extension study (NCT02735915) followed 70 participants who received two HZ/su doses in the initial trial (NCT00434577). Blood samples to assess the cellular (intracellular cytokine staining) and humoral (ELISA) immunity were taken at year nine post-initial vaccination.Results: Participants' mean age at dose 1 was 72.3years. The fold increases over pre-vaccination in the mean frequency of gE-specific CD4+ T-cells expressing 2 activation markers plateaued from year four post-dose 1 until year nine. Anti-gE antibody geometric mean concentrations plateaued and remained above pre-vaccination levels from year four onwards. Immunogenicity at year nine was similar across age strata (60-69, 70years) and confirmed statistical prediction model results using data for up to year six. Further modeling using all data up to year nine predicted immune responses would remain above the pre-vaccination level up to year 15.Conclusion: In adults aged 60years, HZ/su-induced immunogenicity remained above pre-vaccination levels for at least nine years post-initial vaccination.Summary: After vaccination with HZ/su, both cell mediated and humoral immunity remained above pre-vaccination levels up to year 9 regardless of age group. Immune responses are predicted to remain above baseline up to 15years post initial vaccination.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS INC , 2018. Vol. 14, no 6, p. 1370-1377
Keywords [en]
herpes zoster (shingles) vaccine, herpes zoster, immunity, persistence, prediction modeling, prevention, subunit gE vaccine, varicella-zoster virus
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Immunology in the medical area
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URN: urn:nbn:se:uu:diva-361012DOI: 10.1080/21645515.2018.1442162ISI: 000436838100019PubMedID: 29461919OAI: oai:DiVA.org:uu-361012DiVA, id: diva2:1249863
Available from: 2018-09-20 Created: 2018-09-20 Last updated: 2019-02-01Bibliographically approved

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Rombo, Lars

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Department of Medical Biochemistry and MicrobiologyCentrum för klinisk forskning i Sörmland (CKFD)
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