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The pro-inflammatory role of platelets in cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2018 (English)In: Platelets, ISSN 0953-7104, E-ISSN 1369-1635, Vol. 29, no 6, p. 569-573Article in journal (Refereed) Published
Abstract [en]

Thrombosis is a frequent issue in cancer patients. Tumor-induced platelet activation and coagulation does not only constitute a significant risk for thrombosis, but also contribute to tumor progression by promoting critical processes such as angiogenesis and metastasis. In addition to their role in hemostasis, platelets are increasingly recognized as regulators of inflammation. By modulating the immune system, platelets regulate several aspects of cancer-associated pathology. Platelets influence the inflammatory response in cancer by affecting the activation status of the endothelium and by recruiting leukocytes to primary and metastatic tumor sites, as well as to distant organs unaffected by tumor growth. Furthermore, platelets participate in the formation of neutrophil extracellular traps, which can promote metastasis, thrombosis, and contribute to organ failure. In this review, we discuss the role of platelets as coordinators of the immune system during malignant disease and the potential of targeting platelets to prevent cancer-associated pathology.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS INC , 2018. Vol. 29, no 6, p. 569-573
Keywords [en]
Cancer, inflammation, NETs, neutrophil extracellular traps, neutrophils, platelets
National Category
Cancer and Oncology Cell Biology
Identifiers
URN: urn:nbn:se:uu:diva-362860DOI: 10.1080/09537104.2018.1453059ISI: 000441736900006PubMedID: 29584534OAI: oai:DiVA.org:uu-362860DiVA, id: diva2:1255310
Available from: 2018-10-11 Created: 2018-10-11 Last updated: 2018-10-11Bibliographically approved

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Olsson, Anna-KarinCedervall, Jessica

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