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Reply to Caetano-Anolles et al. comment on "Empirical genome evolution models root the tree of life"
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Biology.ORCID iD: 0000-0001-7468-7317
Lund Univ, Dept Biol, Lund, Sweden.
2018 (English)In: Biochimie, ISSN 0300-9084, E-ISSN 1638-6183, Vol. 149, p. 137-138Article in journal, Letter (Other academic) Published
Abstract [en]

We recently analyzed the robustness of competing evolution models developed to identify the root of the Tree of Life: 1) An empirical Sankoff parsimony (ESP) model (Harish and Kurland, 2017), which is a nonstationary and directional evolution model; and 2) An a priori ancestor (APA) model (Kim and Caetano-Anolles, 2011) that is a stationary and reversible evolution model. Both Bayesian model selection tests as well as maximum parsimony analyses demonstrate that the ESP model is, overwhelmingly, the better model. Moreover, we showed that the APA model is not only sensitive to artifacts, but also that the underlying assumptions are neither empirically grounded nor biologically realistic.

Place, publisher, year, edition, pages
2018. Vol. 149, p. 137-138
Keywords [en]
Evolution, Phylogenomics, Proteome, Selection, Tree of life
National Category
Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-362652DOI: 10.1016/j.biochi.2018.04.002ISI: 000434053100015PubMedID: 29631014OAI: oai:DiVA.org:uu-362652DiVA, id: diva2:1256107
Available from: 2018-10-16 Created: 2018-10-16 Last updated: 2018-10-16Bibliographically approved

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