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Kidney outer medulla mitochondria are more efficient compared with cortex mitochondria as a strategy to sustain ATP production in a suboptimal environment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Linkoping Univ, Dept Med & Hlth Sci, Dept Radiol Norrkoping, Linkoping, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Cell Biology. Uppsala Univ, Dept Med Cell Biol, Uppsala, Sweden.
Linkoping Univ, Dept Med & Hlth Sci, Dept Radiol Norrkoping, Linkoping, Sweden.
2018 (English)In: American Journal of Physiology - Renal Physiology, ISSN 1931-857X, E-ISSN 1522-1466, Vol. 315, no 3, p. F677-F681Article in journal (Refereed) Published
Abstract [en]

The kidneys receive similar to 25% of cardiac output, which is a prerequisite to maintain sufficient glomerular filtration rate. However, both intrarenal regional renal blood flow and tissue oxygen levels are heterogeneous with decreasing levels in the inner part of the medulla. These differences, in combination with the heterogeneous metabolic activity of the different nephron segment located in the different parts of the kidney, may constitute a functional problem when challenged. The proximal tubule and the medullary thick ascending limb of Henle are considered to have the highest metabolic rate, which is related to the high mitochondria content needed to sustain sufficient ATP production from oxidative phosphorylation to support high electrolyte transport activity in these nephron segments. Interestingly, the cells located in kidney medulla function at the verge of hypoxia, and the mitochondria may have adapted to the surrounding environment. However, little is known about intrarenal differences in mitochondria function. We therefore investigated functional differences between mitochondria isolated from kidney cortex and medulla of healthy normoglycemic rats by using high-resolution respirometry. The results demonstrate that medullary mitochondria had a higher degree of coupling, are more efficient, and have higher oxygen affinity, which would make them more suitable to function in an environment with limited oxygen supply. Furthermore, these results support the hypothesis that mitochondria of medullary cells have adapted to the normal hypoxic in vivo situation as a strategy of sustaining ATP production in a suboptimal environment.

Place, publisher, year, edition, pages
AMER PHYSIOLOGICAL SOC , 2018. Vol. 315, no 3, p. F677-F681
Keywords [en]
cortex, kidney, medulla, mitochondria, oxygen affinity, P/O ratio
National Category
Physiology
Identifiers
URN: urn:nbn:se:uu:diva-364249DOI: 10.1152/ajprenal.00207.2018ISI: 000444017300015PubMedID: 29846107OAI: oai:DiVA.org:uu-364249DiVA, id: diva2:1258455
Funder
Swedish Research CouncilSwedish Diabetes AssociationErnfors FoundationAvailable from: 2018-10-24 Created: 2018-10-24 Last updated: 2018-10-24Bibliographically approved

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Schiffer, Tomas A.

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