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The Influence of Rearing on Behavior, Brain Monoamines, and Gene Expression in Three-Spined Sticklebacks
Linkoping Univ, IFM Biol, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden.
Linkoping Univ, IFM Biol, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden.
Linkoping Univ, IFM Biol, Dept Phys Chem & Biol, SE-58183 Linkoping, Sweden.ORCID iD: 0000-0002-1622-5752
Stockholm Univ, Dept Zool, Stockholm, Sweden.
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2018 (English)In: Brain, behavior, and evolution, ISSN 0006-8977, E-ISSN 1421-9743, Vol. 91, no 4, p. 201-213Article in journal (Refereed) Published
Abstract [en]

The causes of individual variation in behavior are often not well understood, and potential underlying mechanisms include both intrinsic and extrinsic factors, such as early environmental, physiological, and genetic differences. In an exploratory laboratory study, we raised three-spined sticklebacks (Gasterosteus aculeatus) under 4 different environmental conditions (simulated predator environment, complex environment, variable social environment, and control). We investigated how these manipulations related to behavior, brain physiology, and gene expression later in life, with focus on brain dopamine and serotonin levels, turnover rates, and gene expression. The different rearing environments influenced behavior and gene expression, but did not alter monoamine levels or metabolites. Specifically, compared to control fish, fish exposed to a simulated predator environment tended to be less aggressive, more exploratory, and more neophobic; and fish raised in both complex and variable social environments tended to be less neophobic. Exposure to a simulated predator environment tended to lower expression of dopamine receptor DRD4A, a complex environment increased expression of dopamine receptor DRD1B, while a variable social environment tended to increase serotonin receptor 5-HTR2B and serotonin transporter SLC6A4A expression. Despite both behavior and gene expression varying with early environment, there was no evidence that gene expression mediated the relationship between early environment and behavior. Our results confirm that environmental conditions early in life can affect phenotypic variation. However, the mechanistic pathway of the monoaminergic systems translating early environmental variation into observed behavioral responses was not detected.

Place, publisher, year, edition, pages
KARGER , 2018. Vol. 91, no 4, p. 201-213
Keywords [en]
Dopamine, Fish, Novel arena, Novel object, Personality, Serotonin
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-364484DOI: 10.1159/000489942ISI: 000443740100002PubMedID: 29961048OAI: oai:DiVA.org:uu-364484DiVA, id: diva2:1259293
Funder
Lars Hierta Memorial FoundationAvailable from: 2018-10-29 Created: 2018-10-29 Last updated: 2018-10-29Bibliographically approved

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Dahlbom, JosefinWinberg, Svante

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