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SKUP(3) RCT; continuous study: Changes in sleepiness and quality of life after modified UPPP.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Öron-, näs- och halssjukdomar.
2016 (engelsk)Inngår i: The Laryngoscope, ISSN 0023-852X, E-ISSN 1531-4995, Vol. 26, nr 6Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objectives/Hypothesis

Our previous study showed that modified uvulopalatopharyngoplasty (UPPP), including tonsillectomy, significantly improved nocturnal respiration in obstructive sleep apnea syndrome (OSAS) patients. This is a continuous study of changes in daytime sleepiness and quality of life.

Study Design

Prospective randomized controlled trial (RCT), two parallel arms.

Methods

Sixty‐five patients with apnea‐hypopnea index ≥ 15, body mass index < 36, Epworth Sleepiness Scale (ESS) ≥ 8, Friedman stage I or II, failing nonsurgical treatment. The intervention group (n = 32) underwent surgery, and the controls (n = 33) had no treatment. At baseline and the 7‐month follow‐up, polysomnography, questionnaires, and vigilance tests were implemented.

Results

All patients answered the questionnaires, and 48 took the vigilance test. Epworth Sleepiness Scale decreased significantly in the intervention group, from a mean (standard deviation) of 12.5(3.2) to 6.8(3.9), but nonsignificantly in the control group, from 12.9(3.1) to 12.5(3.9), a significant group difference (P < 0.001). The physical and mental component score on the Short Form‐36 questionnaire increased significantly in the intervention group, from a mean 47.8(8.3) to 51.2(8.8) and from 42.1(10.6) to 48.1(9.7), respectively, but with nonsignificant changes in the controls: 49.0(9.0) to 48.3(9.1) and 41.0(10.2) to 42.7(11.5), significant group differences (P = 0.007, P = 0.031), respectively. The sleep latency/vigilance test showed a significant mean increase in the intervention group of 7(12.4) minutes and a decrease in the controls of 2.2(10.6), a significant group difference (P = 0.011). There were significant correlations between changes in subjective outcomes and nocturnal respiration.

Conclusion

This RCT shows that modified UPPP was effective in improving daytime sleepiness and quality of life in OSAS patients. It strengthens the body of evidence on the potential effect of surgery offered to selected patients.

sted, utgiver, år, opplag, sider
2016. Vol. 26, nr 6
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-364592DOI: 10.1002/lary.25642OAI: oai:DiVA.org:uu-364592DiVA, id: diva2:1259522
Tilgjengelig fra: 2018-10-30 Laget: 2018-10-30 Sist oppdatert: 2019-02-28bibliografisk kontrollert

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