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Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, International Maternal and Child Health (IMCH), International Child Health and Nutrition.
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2018 (English)In: Emerging Infectious Diseases, ISSN 1080-6040, E-ISSN 1080-6059, Vol. 24, no 8, p. 1591-1593Article in journal, Letter (Refereed) Published
Abstract [en]

Dihydroartemisinin/piperaquine (DHA/PPQ) is increasingly deployed as antimalaria drug in Africa. We report the detection in Mali of Plasmodium falciparum infections carrying plasmepsin 2 duplications (associated with piperaquine resistance) in 7/65 recurrent infections within 2 months after DHA/PPQ treatment. These findings raise concerns about the long-term efficacy of DHA/PPQ treatment in Africa.

Place, publisher, year, edition, pages
Centers for Disease Control and Prevention , 2018. Vol. 24, no 8, p. 1591-1593
Keywords [en]
DHA-PPQ, Pfpm2, Plasmodium falciparum, West Africa, dihydroartemisinin-piperaquine, malaria, moquitoborne diseases, piperaquine, plasmepsin 2, resistance, vector-borne infections
National Category
Public Health, Global Health, Social Medicine and Epidemiology Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-364645DOI: 10.3201/eid2408.180370ISI: 000439050300038PubMedID: 29798744OAI: oai:DiVA.org:uu-364645DiVA, id: diva2:1259669
Funder
Swedish Research Council, VR-2014-3134Sida - Swedish International Development Cooperation AgencyAvailable from: 2018-10-30 Created: 2018-10-30 Last updated: 2018-11-21Bibliographically approved

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Mårtensson, Andreas

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