uu.seUppsala universitets publikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Amygdala reactivity and connectivity during social and non-social aversive stimulation in social anxiety disorder
Karolinska Inst, Dept Clin Neurosci, Nobels Vag 9, Stockholm, Sweden;Masaryk Univ, Cent European Inst Technol, Ctr Neurosci, Brno, Czech Republic;Masaryk Univ, Fac Med, Brno, Czech Republic.
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Masaryk Univ, Fac Med, Brno, Czech Republic.ORCID-id: 0000-0003-2516-9075
Stockholm Univ, Dept Psychol, Stockholm, Sweden.
Karolinska Inst, Dept Clin Neurosci, Nobels Vag 9, Stockholm, Sweden.
Visa övriga samt affilieringar
2018 (Engelska)Ingår i: Psychiatry Research: Neuroimaging, ISSN 0925-4927, E-ISSN 1872-7506, Vol. 280, s. 56-61Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Social anxiety disorder (SAD) is characterized by exaggerated amygdala reactivity in response to symptom provocation, but it is unclear if such hyper-reactivity is elicited by disorder-specific challenges only or characterizes reactions to aversive stimuli in general. Here, using functional magnetic resonance imaging in 14 patients with SAD, as compared to 12 healthy controls, we found that amygdala hyper-reactivity is confined to disorder-relevant social stimulation. SAD patients displayed increased amygdala reactivity to fearful as compared to neutral facial pictures, but not in response to generally aversive but mainly non-social stimulation when compared to neutral pictorial stimuli taken from the International Affective Picture System. The increased amygdala reactivity was not mediated by an altered prefrontal inhibition among SAD patients as compared to controls, suggesting increased bottom-up processes rather than attenuated top-down control. In conclusion, the enhanced amygdala reactivity in SAD seems specific to socially relevant stimuli rather than aversive stimuli in general.

Ort, förlag, år, upplaga, sidor
2018. Vol. 280, s. 56-61
Nyckelord [en]
Social phobia, Emotional faces, International Affective Picture System, IAPS, fMRI, Fear
Nationell ämneskategori
Psykiatri
Identifikatorer
URN: urn:nbn:se:uu:diva-364125DOI: 10.1016/j.pscychresns.2018.08.012ISI: 000443824900008PubMedID: 30165271OAI: oai:DiVA.org:uu-364125DiVA, id: diva2:1260780
Forskningsfinansiär
VetenskapsrådetRiksbankens JubileumsfondRiksbankens JubileumsfondHjärnfondenTillgänglig från: 2018-11-05 Skapad: 2018-11-05 Senast uppdaterad: 2018-11-05Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Frick, AndreasFredriksson, MatsFurmark, Tomas

Sök vidare i DiVA

Av författaren/redaktören
Frick, AndreasFredriksson, MatsFurmark, Tomas
Av organisationen
Institutionen för psykologi
I samma tidskrift
Psychiatry Research: Neuroimaging
Psykiatri

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 21 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf