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Incorporation of 4'-C-aminomethyl-2'-O-methylthymidine into DNA by thermophilic DNA polymerases
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.ORCID iD: 0000-0002-7256-0758
2012 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 48, no 77, p. 9619-9621Article in journal (Refereed) Published
Abstract [en]

The dual modified nucleotide 4'-C-aminomethyl-2'-O-methylthymidine 5'-triphosphate was synthesized and enzymatically incorporated into DNA by the thermophilic DNA polymerases Pfu and Therminator III. The dual ribose modification imparted increased exonuclease resistance to DNA compared to the well-known 2'-O-methyl modification.

Place, publisher, year, edition, pages
2012. Vol. 48, no 77, p. 9619-9621
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Biochemistry and Molecular Biology
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URN: urn:nbn:se:uu:diva-364934DOI: 10.1039/c2cc35222bPubMedID: 22908130OAI: oai:DiVA.org:uu-364934DiVA, id: diva2:1261196
Available from: 2018-11-06 Created: 2018-11-06 Last updated: 2019-03-29Bibliographically approved

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Nawale, Ganesh N.

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