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Chemistry of Heterocyclic Five and Six Membered Enamino Nitriles and Enamino Esters
Univ Kuwait, Dept Chem, Fac Sci, POB 5969, Safat 13060, Kuwait.
Univ Kuwait, Dept Chem, Fac Sci, POB 5969, Safat 13060, Kuwait.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Farmakognosi. Univ Karachi, Res Inst Chem, ICCBS, Karachi 75270, Pakistan;Menoufia Univ, Chem Dept, Fac Sci, Menoufia, Egypt.
Cairo Univ, Dept Chem, Fac Sci, POB 12613, Giza, Egypt.
2018 (English)In: Mini-Reviews in medical chemistry, ISSN 1389-5575, E-ISSN 1875-5607, Vol. 18, no 12, p. 992-1007Article, review/survey (Refereed) Published
Abstract [en]

Progress in the chemistry of cyclic enamino-nitriles based on the advanced synthetic methodologies is reported. Due to the recent accomplishment, it becomes possible to reactivate these molecules toward electrophiles, nucleophiles and as electron rich dienes in 2+3 dipolar additions and in 4+2 cycloadditions reactions. Synthesizing the poly functionalized 4H-pyrans and their fused derivatives is a fascinating field with a multitude of biological implications such as antitumor, cardiotonic, hepatoprotective, antihypertensive, antibronchitis, as well antifungal activity. This work was conducted with particular emphasis on reviewing the work done on the cyclic enamines since 1990 up till now in order to highlight in more details the synthetic pathways, interactions and the biological activities, Furthermore; we referred to the recent original data of our group contributions within this field.

Place, publisher, year, edition, pages
2018. Vol. 18, no 12, p. 992-1007
Keywords [en]
Cyclic enamines, cycloaddition, electrophiles, nucleophiles, functionally substituted enamines, biological activity
National Category
Organic Chemistry Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-365137DOI: 10.2174/1389557516666161130100610ISI: 000435093300001OAI: oai:DiVA.org:uu-365137DiVA, id: diva2:1262176
Funder
Swedish Research Council, 2016-05908Available from: 2018-11-09 Created: 2018-11-09 Last updated: 2018-11-09Bibliographically approved

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El-Seedi, Hesham

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