uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Designing A Commercial Biomaterial For A Specific Unmet Clinical Need –: An Adhesive Odyssey
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Materials in medicine)
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. Uppsala University. (Tillämpad materialvetenskap, Applied Materials Sciences)ORCID iD: 0000-0001-7004-2853
Uppsala University, Disciplinary Domain of Science and Technology, Technology, Department of Engineering Sciences, Applied Materials Sciences. (Tillämpad materialvetenskap, Applied Materials Sciences)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
Show others and affiliations
2018 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

There are clinical situations in fracture repair, e.g. osteochondral fragments, where current implant hardware is insufficient. The proposition of an adhesive enabling fixation and healing has been considered but no successful candidate has emerged thus far. The many preclinical and few clinical attempts include fibrin glue, mussel adhesive and even “Kryptonite” (US bone void filler). The most promising recent attempts are based on phosphorylating amino acids, part of a common cellular adhesion mechanism linking mussels, caddis fly larvae, and mammals. Rapid high bond strength development in the wetted fatty environment of fractured bone, that is sustained during biological healing, is challenging to prove both safety and efficacy. Additionally, there are no “predicate” preclinical animal and human models which led the authors to develop novel evaluations for an adhesive candidate “OsStictm” based on calcium salts and amino acids. Adhesive formulations were evaluated in both soft (6/12 weeks) and hard tissue (3,7,10,14 & 42 days) safety studies in murine models. The feasibility of a novel adhesiveness test, initially proven in murine cadaver femoral bone, is being assessed in-vivo (3,7,10,14 & 42 days) in bilateral implantations with a standard tissue glue as the control. In parallel an ex-vivo human bone model using freshly harvested human donor bone is under development to underwrite the eventual clinical application of such an adhesive. This is part of a risk mitigation project bridging between laboratory biomaterial characterisation and a commercial biomaterial development where safety and effectiveness have to meet today´s new medical device requirements.

Place, publisher, year, edition, pages
2018.
Keywords [en]
Tissue adhesive, biomaterial, calcium phosphate
National Category
Medical Materials Composite Science and Engineering Ceramics Biomaterials Science
Research subject
Engineering Science with specialization in Materials Science
Identifiers
URN: urn:nbn:se:uu:diva-366369OAI: oai:DiVA.org:uu-366369DiVA, id: diva2:1264453
Conference
26th EORS Annual Meeting 25th – 28th September 2018, Galway, Ireland
Funder
Swedish Foundation for Strategic Research , RMA15-0110Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2019-03-06Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

http://www.eors2018.org/

Authority records BETA

Pujari-Palmer, MichaelHulsart Billström, GryLarsson, SuneEngqvist, Håkan

Search in DiVA

By author/editor
Pujari-Palmer, MichaelHulsart Billström, GryLarsson, SuneEngqvist, Håkan
By organisation
Applied Materials SciencesOrthopaedics
Medical MaterialsComposite Science and EngineeringCeramicsBiomaterials Science

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 129 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf