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Sulfonyl Fluorides (SFs): More Than Click Reagents?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Drug Design and Discovery.ORCID iD: 0000-0002-8344-2415
Univ KwaZulu Natal, Catalysis & Peptide Res Unit, Durban, South Africa;Karolinska Inst, Sci Life Lab, Drug Discovery & Dev Platform, Stockholm, Sweden;Karolinska Inst, Div Translat Med & Chem Biol, Dept Med Biochem & Biophys, Stockholm, Sweden.ORCID iD: 0000-0002-9453-6812
2018 (English)In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, no 27-28, p. 3648-3666Article, review/survey (Refereed) Published
Abstract [en]

Sulfonyl fluoride (SF) containing substances are currently attracting enormous attention among practitioners of both chemical biology and synthetic organic chemistry. The groups of Jones and Liskamp have demonstrated the potential of sulfonyl fluorides as selective covalent inhibitors in studies related to drug discovery and chemical biology, respectively, in the last few years. The Sharpless group has extended the repertoire of click-reactions to those involving sulfonyl fluorides, that is, sulfur-fluoride exchange (SuFEx), a development that quickly triggered the interest in this functional group in the community of synthetic organic chemists. In this microreview, we aim to give an account of the synthetic chemistry surrounding sulfonyl fluoride containing substances from a historical perspective to present day developments.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2018. no 27-28, p. 3648-3666
Keywords [en]
Sulfonyl fluoride, Orthogonal reactions, Sulfur-fluoride exchange, Click chemistry, Fluorides, Synthesis design
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-366456DOI: 10.1002/ejoc.201800464ISI: 000439775200008OAI: oai:DiVA.org:uu-366456DiVA, id: diva2:1265247
Available from: 2018-11-22 Created: 2018-11-22 Last updated: 2018-11-22Bibliographically approved

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Chinthakindi, Praveen K.

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