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Development of a Sensitive Induction-Based Magnetic Nanoparticle Biodetection Method.
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2018 (English)In: Nanomaterials (Basel, Switzerland), E-ISSN 2079-4991, Vol. 8, no 11, article id E887Article in journal (Refereed) Published
Abstract [en]

We developed a novel biodetection method for influenza virus based on AC magnetic susceptibility measurement techniques (the DynoMag induction technique) together with functionalized multi-core magnetic nanoparticles. The sample consisting of an incubated mixture of magnetic nanoparticles and rolling circle amplified DNA coils is injected into a tube by a peristaltic pump. The sample is moved as a plug to the two well-balanced detection coils and the dynamic magnetic moment in each position is read over a range of excitation frequencies. The time for making a complete frequency sweep over the relaxation peak is about 5 minutes (10 Hz⁻10 kHz with 20 data points). The obtained standard deviation of the magnetic signal at the relaxation frequency (around 100 Hz) is equal to about 10-5 (volume susceptibility SI units), which is in the same range obtained with the DynoMag system. The limit of detection with this method is found to be in the range of 1 pM.

Place, publisher, year, edition, pages
2018. Vol. 8, no 11, article id E887
Keywords [en]
AC susceptibility, Brownian relaxation, magnetic biosensing, magnetic nanoparticles, multi-core particles
National Category
Nano Technology
Research subject
Engineering Science with specialization in Nanotechnology and Functional Materials
Identifiers
URN: urn:nbn:se:uu:diva-366859DOI: 10.3390/nano8110887ISI: 000451316100022PubMedID: 30388776OAI: oai:DiVA.org:uu-366859DiVA, id: diva2:1265843
Funder
Swedish Foundation for Strategic Research Available from: 2018-11-26 Created: 2018-11-26 Last updated: 2019-01-24Bibliographically approved

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Zardán Gómez de la Torre, TeresaStrömme, Maria

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