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Development of a Sensitive Induction-Based Magnetic Nanoparticle Biodetection Method.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Nanomaterials (Basel, Switzerland), E-ISSN 2079-4991, Vol. 8, nr 11, artikkel-id E887Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We developed a novel biodetection method for influenza virus based on AC magnetic susceptibility measurement techniques (the DynoMag induction technique) together with functionalized multi-core magnetic nanoparticles. The sample consisting of an incubated mixture of magnetic nanoparticles and rolling circle amplified DNA coils is injected into a tube by a peristaltic pump. The sample is moved as a plug to the two well-balanced detection coils and the dynamic magnetic moment in each position is read over a range of excitation frequencies. The time for making a complete frequency sweep over the relaxation peak is about 5 minutes (10 Hz⁻10 kHz with 20 data points). The obtained standard deviation of the magnetic signal at the relaxation frequency (around 100 Hz) is equal to about 10-5 (volume susceptibility SI units), which is in the same range obtained with the DynoMag system. The limit of detection with this method is found to be in the range of 1 pM.

sted, utgiver, år, opplag, sider
2018. Vol. 8, nr 11, artikkel-id E887
Emneord [en]
AC susceptibility, Brownian relaxation, magnetic biosensing, magnetic nanoparticles, multi-core particles
HSV kategori
Forskningsprogram
Teknisk fysik med inriktning mot nanoteknologi och funktionella material
Identifikatorer
URN: urn:nbn:se:uu:diva-366859DOI: 10.3390/nano8110887ISI: 000451316100022PubMedID: 30388776OAI: oai:DiVA.org:uu-366859DiVA, id: diva2:1265843
Forskningsfinansiär
Swedish Foundation for Strategic Research Tilgjengelig fra: 2018-11-26 Laget: 2018-11-26 Sist oppdatert: 2019-01-24bibliografisk kontrollert

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