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Pseudoexfoliation and aortic aneurysm: a long-term follow-up study
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Ophthalmology.ORCID iD: 0000-0002-8265-6518
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
2019 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 97, no 1, p. 80-83Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To study the relationship between pseudoexfoliation (PEX) and aortic aneurysm in a population with a high prevalence of PEX.

METHODS: Survival analyses were performed in a cohort of 735 residents aged 65-74 years, examined in a population survey in the municipality of Tierp, Sweden, 1984-1986. To expand the sample size, 1040 people were recruited by means of glaucoma case records established at the Eye Department in Tierp in 1978-2007. In this way, the cohort comprised 1775 subjects, representing more than 25 400 person-years at risk. Medical records and autopsy reports were reviewed to identify subjects diagnosed with aneurysm. Those with a follow-up time shorter than 1 year were excluded.

RESULTS: By the end of the study in September 2017, 60 new cases of aortic aneurysm had been found. Of these cases, 23% (14 subjects) were affected by PEX at baseline, compared with 28% among subjects without aneurysm. No association between PEX and aortic aneurysm was found (hazard ratio 0.97; 95% confidence interval 0.53-1.77).

CONCLUSION: In this population-based study, we were unable to verify a relationship between PEX and the development of aortic aneurysm.

Place, publisher, year, edition, pages
2019. Vol. 97, no 1, p. 80-83
Keywords [en]
Epidemiology, Pseudoexfoliation, aortic aneurysm, exfoliation syndrome, risk factor, vascular disease
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:uu:diva-367265DOI: 10.1111/aos.13882ISI: 000456872000021PubMedID: 30238683OAI: oai:DiVA.org:uu-367265DiVA, id: diva2:1266788
Available from: 2018-11-29 Created: 2018-11-29 Last updated: 2019-03-07Bibliographically approved

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Ekström, CurtWanhainen, Anders

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