Pseudoexfoliation and aortic aneurysm: a long-term follow-up study
2019 (Engelska)Ingår i: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 97, nr 1, s. 80-83Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
PURPOSE: To study the relationship between pseudoexfoliation (PEX) and aortic aneurysm in a population with a high prevalence of PEX.
METHODS: Survival analyses were performed in a cohort of 735 residents aged 65-74 years, examined in a population survey in the municipality of Tierp, Sweden, 1984-1986. To expand the sample size, 1040 people were recruited by means of glaucoma case records established at the Eye Department in Tierp in 1978-2007. In this way, the cohort comprised 1775 subjects, representing more than 25 400 person-years at risk. Medical records and autopsy reports were reviewed to identify subjects diagnosed with aneurysm. Those with a follow-up time shorter than 1 year were excluded.
RESULTS: By the end of the study in September 2017, 60 new cases of aortic aneurysm had been found. Of these cases, 23% (14 subjects) were affected by PEX at baseline, compared with 28% among subjects without aneurysm. No association between PEX and aortic aneurysm was found (hazard ratio 0.97; 95% confidence interval 0.53-1.77).
CONCLUSION: In this population-based study, we were unable to verify a relationship between PEX and the development of aortic aneurysm.
Ort, förlag, år, upplaga, sidor
2019. Vol. 97, nr 1, s. 80-83
Nyckelord [en]
Epidemiology, Pseudoexfoliation, aortic aneurysm, exfoliation syndrome, risk factor, vascular disease
Nationell ämneskategori
Oftalmologi
Identifikatorer
URN: urn:nbn:se:uu:diva-367265DOI: 10.1111/aos.13882ISI: 000456872000021PubMedID: 30238683OAI: oai:DiVA.org:uu-367265DiVA, id: diva2:1266788
2018-11-292018-11-292019-03-07Bibliografiskt granskad