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Serum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and Its Subtypes.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Orthopaedics.
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2018 (English)In: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 49, no 10, p. 2508-2511Article in journal (Refereed) Published
Abstract [en]

Background and Purpose- Observational studies have reported increased risk of ischemic stroke among individuals with low serum 25-hydroxyvitamin D (S-25OHD) concentrations but uncertainty remains about the causality of this association. We sought to determine whether S-25OHD concentrations are causally associated with ischemic stroke and its subtypes using Mendelian randomization. Methods- We used summary-level data for ischemic stroke (34 217 cases and 404 630 noncases) from the MEGASTROKE consortium. As instruments, we used 6 single nucleotide polymorphisms, explaining 7.5% of the variance in S-25OHD, previously identified to be associated with S-25OHD concentrations in the Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits consortium (n=79 366). The analyses were conducted using the inverse-variance-weighted method and complemented with the weighted median, heterogeneity-penalized, and Mendelian randomization-Egger approaches. Results- Genetically higher S-25OHD concentration was not associated with ischemic stroke. The odds ratios (95% CI) per genetically predicted 1-SD (≈18 nmol/L) increase in S-25OHD concentrations, based on all 6 single nucleotide polymorphisms, were 1.01 (0.94-1.08; P=0.84) for all ischemic stroke, 0.94 (0.80-1.11; P=0.49) for large artery stroke, 0.95 (0.82-1.11; P=0.55) for small vessel stroke, and 1.02 (0.90-1.16; P=0.74) for cardioembolic stroke. The results were similar in sensitivity analyses. Conclusions- These findings provide no support that higher S-25OHD concentrations are causally associated with any ischemic stroke subtype. Thus, vitamin D supplementation will unlikely reduce the risk of ischemic stroke in the general population.

Place, publisher, year, edition, pages
2018. Vol. 49, no 10, p. 2508-2511
Keywords [en]
25-hydroxyvitamin D, polymorphisms, single nucleotide, random allocation, stroke, vitamin D
National Category
Orthopaedics Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-367519DOI: 10.1161/STROKEAHA.118.022242ISI: 000452465400037PubMedID: 30355092OAI: oai:DiVA.org:uu-367519DiVA, id: diva2:1267236
Available from: 2018-11-30 Created: 2018-11-30 Last updated: 2019-11-19Bibliographically approved

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Michaëlsson, Karl

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