Practice Patterns of Stereotactic Radiotherapy in Pediatrics: Results From an International Pediatric Research ConsortiumShow others and affiliations
2018 (English)In: Journal of pediatric hematology/oncology (Print), ISSN 1077-4114, E-ISSN 1536-3678, Vol. 40, no 7, p. 522-526Article in journal (Refereed) Published
Abstract [en]
Purpose/Objectives: There is little consensus regarding the application of stereotactic radiotherapy (SRT) in pediatrics. We evaluated patterns of pediatric SRT practice through an international research consortium. Materials and Methods: Eight international institutions with pediatric expertise completed a 124-item survey evaluating patterns of SRT use for patients 21 years old and younger. Frequencies of SRT use and median margins applied with and without SRT were evaluated. Results: Across institutions, 75% reported utilizing SRT in pediatrics. SRT was used in 22% of brain, 18% of spine, 16% of other bone, 16% of head and neck, and <1% of abdomen/pelvis, lung, and liver cases across sites. Of the hypofractionated SRT cases, 42% were delivered with definitive intent. Median gross tumor volume to planning target volume margins for SRT versus non-SRT plans were 0.2 versus 1.4 cm for brain, 0.3 versus 1.5 cm for spine/other bone, 0.3 versus 2.0 cm for abdomen/pelvis, 0.7 versus 1.5 cm for head and neck, 0.5 versus 1.7 cm for lung, and 0.5 versus 2.0 cm for liver sites. Conclusions: SRT is commonly utilized in pediatrics across a range of treatment sites. Margins used for SRT were substantially smaller than for non-SRT planning, highlighting the utility of this approach in reducing treatment volumes.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2018. Vol. 40, no 7, p. 522-526
Keywords [en]
pediatric stereotactic radiosurgery, stereotactic radiosurgery, stereotactic body radiation therapy
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-367409DOI: 10.1097/MPH.0000000000001290ISI: 000446191900024PubMedID: 30247288OAI: oai:DiVA.org:uu-367409DiVA, id: diva2:1267657
2018-12-032018-12-032018-12-03Bibliographically approved