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Molecular allergy diagnostics refine characterization of children sensitized to dog dander
Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, S1,Sjukhusbacken 10, S-11883 Stockholm, Sweden.
Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden;Karolinska Inst, Dept Med, Solna Immunol & Allergy Unit, Stockholm, Sweden;Karolinska Univ Hosp, Stockholm, Sweden.
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Research group (Dept. of women´s and children´s health), Paediatric Inflammation Research. Thermo Fisher Sci, Uppsala, Sweden.
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2018 (English)In: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 142, no 4, p. 1113-+Article in journal (Refereed) Published
Abstract [en]

Background: Sensitization to dog dander is an important risk factor for rhinoconjunctivitis and asthma but is not sufficient for diagnosing dog allergy. Molecular allergy diagnostics offer new opportunities for refined characterization. Objectives: We sought to study the association between sensitization to all presently known dog allergen components and clinical symptoms of dog allergy in children evaluated by using nasal provocation tests (NPTs). Methods: Sixty children (age, 10-18 years) sensitized to dog dander extract underwent NPTs with dog dander extract. Measurement of IgE levels to dog dander and to Can f 1, Can f 2, Can f 3, and Can f 5 was performed with ImmunoCAP, and measurement of IgE levels to Can f 4 and Can f 6 was performed with streptavidin ImmunoCAP. An IgE level of 0.1 kU(A)/L or greater was considered positive. Results: There was an association between sensitization to an increasing number of dog allergen components and a positive nasal challenge result (P = .01). Sensitization to lipocalins (odds ratio [OR], 6.0; 95% CI, 1.04-34.5), in particular Can f 4 (OR, 6.80; 95% CI 1.84-25.2) and Can f 6 (OR, 5.69; 95% CI, 1.59-20.8), was associated with a positive NPT result. Monosensitization to Can f 5 was related to a negative NPT result (OR, 5.78; 95% CI, 1.01-33.0). Conclusion: Sensitization to an increasing number of dog allergen components and to lipocalins is associated with dog allergy. Monosensitization to Can f 5 should not be regarded primarily as a marker for dog allergy.

Place, publisher, year, edition, pages
MOSBY-ELSEVIER , 2018. Vol. 142, no 4, p. 1113-+
Keywords [en]
Allergy, Can f 1, Can f 2, Can f 3, Can f 4, Can f 5, Can f 6, children, dog, IgE, molecular allergology, nasal provocation test, sensitization
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-367400DOI: 10.1016/j.jaci.2018.05.012ISI: 000446327300012PubMedID: 29852259OAI: oai:DiVA.org:uu-367400DiVA, id: diva2:1267680
Funder
Swedish Research CouncilSwedish Asthma and Allergy AssociationStockholm County CouncilSwedish Heart Lung FoundationCancer and Allergy FoundationThe Karolinska Institutet's Research FoundationAvailable from: 2018-12-03 Created: 2018-12-03 Last updated: 2018-12-03Bibliographically approved

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Borres, Magnus P

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