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Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.ORCID iD: 0000-0002-8853-2508
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Clinical Research, County of Västmanland.ORCID iD: 0000-0002-3589-6113
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-2174-2068
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
2018 (English)In: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 125, no 11, p. 1601-1626Article, review/survey (Refereed) Published
Abstract [en]

Since the pioneering finding of Caspi and co-workers in 2002 that exposure to childhood maltreatment predicted later antisocial behaviour (ASB) in male carriers of the low-activity MAOA-uVNTR allele, frequent replication studies have been published. Two meta-analyses, one in 2006 and the other in 2014, confirmed the original findings by Caspi and co-workers. In the present paper, we review the literature, note some methodological aspects of candidate gene–environment interaction (cG×E) studies and suggest some future directions. Our conclusions are as follows. (1) The direction of the effect in a cG×E model may differ according to the positive and negative environmental background of the population. (2) There is a predictor-intersection problem such that when measuring one type of maltreatment in a person, other kinds of maltreatment often co-occur. Other forms of abuse are implicitly considered in statistical models; therefore, it is difficult to draw conclusions about the effects of timing and the severity of different forms of stressful life events in relation to ASB. (3) There is also an outcome-intersection problem because of the major intersection of ASB and other forms of mental health problems. It is likely that the G×E with MAOA is related to a common unmeasured factor. (4) For the G×E model, in which the effect of the gene on the outcome variable is dependent on other predictor variables, theoretically, hypothesis-driven statistical modelling is needed.

Place, publisher, year, edition, pages
2018. Vol. 125, no 11, p. 1601-1626
Keywords [en]
Antisocial personality disorder, Brunner syndrome, Conduct disorder, Genetic association studies, Genetic susceptibility, Gene–environment interaction, Juvenile delinquency, Monoamine oxidase A, Review
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-368637DOI: 10.1007/s00702-018-1892-2ISI: 000449118500007PubMedID: 29881923OAI: oai:DiVA.org:uu-368637DiVA, id: diva2:1268501
Funder
The Swedish Brain FoundationForte, Swedish Research Council for Health, Working Life and Welfare, 2015-00897Fredrik och Ingrid Thurings StiftelseStiftelsen Söderström - Königska sjukhemmet, SLS-559921; SLS-655791; SLS-745221Swedish Research Council, VR: 2015-00495EU, FP7, Seventh Framework Programme, INCA 600398Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceAvailable from: 2018-12-06 Created: 2018-12-06 Last updated: 2019-01-08Bibliographically approved

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Nilsson, Kent W.Åslund, CeciliaComasco, ErikaOreland, Lars

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