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Convergent evolution of complex genomic rearrangements in two fungal meiotic drive elements
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Organismal Biology, Systematic Biology.
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2018 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, article id 4242Article in journal (Refereed) Published
Abstract [en]

Meiotic drive is widespread in nature. The conflict it generates is expected to be an important motor for evolutionary change and innovation. In this study, we investigated the genomic consequences of two large multi-gene meiotic drive elements, Sk-2 and Sk-3, found in the filamentous ascomycete Neurospora intermedia. Using long-read sequencing, we generated the first complete and well-annotated genome assemblies of large, highly diverged, non-recombining regions associated with meiotic drive elements. Phylogenetic analysis shows that, even though Sk-2 and Sk-3 are located in the same chromosomal region, they do not form sister clades, suggesting independent origins or at least a long evolutionary separation. We conclude that they have in a convergent manner accumulated similar patterns of tandem inversions and dense repeat clusters, presumably in response to similar needs to create linkage between genes causing drive and resistance.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 9, article id 4242
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Genetics Evolutionary Biology
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URN: urn:nbn:se:uu:diva-368443DOI: 10.1038/s41467-018-06562-xISI: 000447123000018PubMedID: 30315196OAI: oai:DiVA.org:uu-368443DiVA, id: diva2:1269077
Funder
Swedish Research CouncilEU, Horizon 2020, 648143Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceAvailable from: 2018-12-07 Created: 2018-12-07 Last updated: 2018-12-07Bibliographically approved

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Svedberg, JesperHosseini, SaraChen, JunVogan, Aaron A.Lascoux, MartinJohannesson, Hanna

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